… In this review, the role of the complement system in primary membranous nephropathy (MN) …
Finally, the potential role of therapeutic interventions into the complement system in clinical …

… complement activation and proteinuria in a mouse model of membranous nephropathy. …
Proteomic analysis of complement proteins in membranous nephropathy. Kidney Int Reports…

… IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN
… and renal injury associated with mesangial IgA deposition. Although associations between …

… of the basement membrane 1 . The immune deposits consist of immunoglobulin G (IgG),
the relevant antigens and complement components, including the membrane attack complex (…

… system, originally thought to occur mainly via the alternative pathway of complement. … of
renal disease. In this review we summarize the contribution of complement to the IgA- mediated …

… Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome that
progresses to end-stage kidney disease in up to 40% of cases. It is an autoimmune disease …

… (C) Finely granular staining for the complement membrane attack complex, C5b-9, in a
patient with active PMN (original magnification, ×40). Reprinted from reference 89 , with …

… IgA nephropathy patient plasma, 49 , 50 and the presence of C3 fragments in circulating
IgA1-containing IC, 54 suggest systemic complement … and markers of IgA nephropathy severity. …

… to MN: five (3%) patients had interstitial nephritis, five (3%) had a diabetic nephropathy was
diagnosed and two (1%) had IgA nephropathy. These patients had a median eGFR of 51 mL/…

… Based on this finding, we further investigate the pathogenic significance of complement …
a pathogenic role of the complement system in MN, but also suggest a role of complement-…