Hormones and pathogenesis of uterine fibroids
… Studies of postmenopausal women with uterine fibroids receiving only progesterone or a
progestogen are not available, probably because there is no indication for such therapy if the …
progestogen are not available, probably because there is no indication for such therapy if the …
[HTML][HTML] Progesterone signaling in uterine leiomyoma biology: Implications for potential targeted therapy
W Szucio, P Bernaczyk, D Ponikwicka-Tyszko… - Advances in Medical …, 2024 - Elsevier
… Uterine leiomyomas (ULs) are the most common benign smooth muscle cell steroid-dependent
tumors that occur in women of reproductive age. Progesterone (… its nuclear progesterone …
tumors that occur in women of reproductive age. Progesterone (… its nuclear progesterone …
Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics
MS Islam, A Ciavattini, F Petraglia… - Human reproduction …, 2018 - academic.oup.com
… in leiomyoma pathogenesis as well as current and future medical treatments that target ECM
directly or indirectly. Uterine leiomyoma … in pathogenesis and altered bidirectional signaling …
directly or indirectly. Uterine leiomyoma … in pathogenesis and altered bidirectional signaling …
[HTML][HTML] Functional evidence for two distinct mechanisms of action of progesterone and selective progesterone receptor modulator on uterine leiomyomas
G Milewska, D Ponikwicka–Tyszko, P Bernaczyk… - Fertility and …, 2024 - Elsevier
… We showed that both nuclear and membrane progesterone receptors were relevant in
the treatment of uterine leiomyomas, especially when combined with selective progesterone …
the treatment of uterine leiomyomas, especially when combined with selective progesterone …
Wnt/β-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities
… signaling has been shown to mediate a regulatory function in uterine development associated
with progesterone signaling … in responsiveness to progesterone signaling in female mice […
with progesterone signaling … in responsiveness to progesterone signaling in female mice […
[HTML][HTML] Progesterone signaling and uterine fibroid pathogenesis; molecular mechanisms and potential therapeutics
… role progesterone plays in UF pathogenesis [32]. In this article, we reviewed the literature
covering progesterone signaling in UF pathogenesis … via modulation of progesterone signaling, …
covering progesterone signaling in UF pathogenesis … via modulation of progesterone signaling, …
[HTML][HTML] Myometrial progesterone hyper-responsiveness associated with increased risk of human uterine fibroids
… in the uterus, progesterone (P4) also play a key role in UF … There are conflicting results about
the role of progesterone in … the essential role of the progesterone in the pathogenesis of UFs…
the role of progesterone in … the essential role of the progesterone in the pathogenesis of UFs…
Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis
AS Cloud, F Koohestani… - Proceedings of the …, 2022 - National Acad Sciences
… to human uterine leiomyomas, including altered estrogen and progesterone receptor pathways.
… mechanism for the aberrant function of progesterone receptor in uterine leiomyomas. …
… mechanism for the aberrant function of progesterone receptor in uterine leiomyomas. …
The mechanism and function of epigenetics in uterine leiomyoma development
… of progesterone or antiprogestins in uterine leiomyoma tissue. The methylation status of
these genes was further investigated by bisulfite sequencing. The methylation levels of CpG …
these genes was further investigated by bisulfite sequencing. The methylation levels of CpG …
Subtype-specific tumor-associated fibroblasts contribute to the pathogenesis of uterine leiomyoma
… The ovarian hormone dependency of uterine leiomyoma … to be the mitogen of uterine
leiomyomas for decades (14). … for uterine leiomyomas, we established that progesterone (P4) …
leiomyomas for decades (14). … for uterine leiomyomas, we established that progesterone (P4) …