… degradation. There is evidence for an age-related imbalance in reactive oxygen species (…
of chondrocytes that plays a role in cartilage degradation as well as chondrocyte cell death. …

… Prolonged inflammation may shift cartilage homeostasis to the catabolic state, in which
the ECM is degraded via aggrecanases (e.g., a disintegrin and metalloproteinase with …

… joint, including both cartilage and subchondral bone. Reactive oxygen species (ROS) have
… to matrix metalloproteases (MMPs) secretion and degradation of cartilage.14-16 Moreover, …

… joint chondrocytes to maintain cartilage homeostasis, actively … produce an important amount
of reactive species [74], and … on the degradation and oxidation of collagen in cartilage. Thus…

… − ), is significantly higher in the cartilage of OA patients compared with … cartilage-resident
chondrocytes and extracellular matrix (ECM) degradation, which exerts a major pathogenic role …

… Disruption of the cartilage homeostasis in favor of catabolism … This review aimed to assess
the critical role of cartilage … , which are involved in ECM degradation. In comparison with the …

… The reactive oxygen species (ROS) hydrogen peroxide and superoxide are important short-…
Degradation of articular cartilage is a hallmark of osteoarthritis. In the normal embryonic and …

… The role of reactive oxygen species in homeostasis and degradation of cartilage. … arthritis
development in mice by producing reactive oxygen species. J Clin Invest 2007;117:3020-8. 42. …

… leading to synovitis and bone and cartilage degradation. Reactive oxygen species (ROS) are
commonly … The goal of this review is to examine the functions of ROS and related molecular …

… disrupts cellular homeostasis, and changes the structures as well as the functions of cellular
… The degradation and destruction of cartilage are the main features of OA. Many stimuli are …