… are of great importance to therapies targeting inflammation due to their critical role in
regulating inflammation. In many bacterial infections, pathogens activate NLRP3-based …

… inhibitors are reported to be at a disproportionate risk to experience invasive bacterial
infections including pneumococcal infections. Pneumococci are typical colonizers of …

… NLRP3 inflammasomes in response to bacterial infection.39 IRGB10 directly targeted
Gram-negative bacteria … Guanylate-binding proteins mediate the entry of Gram-negative bacteria …

… toxin has a critical role in NLRP3 activation on lung neutrophils. Understanding ATP's
contribution to NLRP3 inflammasome activation in our model of infection will require further …

… Then we analyzed their roles in NLRP3 inflammasome activation in nlrc4 À/À BMDMs.
Compared with wild-type E. piscicida infection, deletion of arcD1/3, potE1/2, or speB could result …

… sensors, which plays a role in the detection of cytosolic infections or disruption. The NLR-…
against various bacterial infections by detecting bacterial flagellin or two bacterial type III …

… components of NLRP3 inflammasome enable it function as … is largely beneficial to the host
defense during infections and … NLRP3 inflammasome assembly in response to bacterial and …

… infection shows IL-1β release via the caspase-8–ASC association [19]. Overall, the activation
of the NLRP3 inflammasome … There are over 500 different types of bacteria in our intestine. …

… of the microbiome and its bacterial components on NLRP3 inflammasome activation and …
bacterial infections must be taken into account in future studies involving NLRP3 inflammasome…

… We hypothesized that higher bacterial burden in AB-8879-infected Nlrp3 −/− mice (Figure
7) might be due to reduced IL-1β production (Figure 4d) and hence reduced neutrophil influx …