TGFβ signaling in the tumor microenvironment

CR Goulet, F Pouliot - Tumor Microenvironment: Signaling Pathways–Part …, 2021 - Springer
… critical roles of TGFβ within the tumor microenvironment may provide new targets for design
of therapeutics against cancer … In tumor microenvironment, TGFβ plays a critical role in tumor

Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy

H Zhao, J Wei, J Sun - International Immunopharmacology, 2020 - Elsevier
… of TGF-β signaling in carcinomas and tumor microenvironment. … of TGF-β blockades used
or being evaluated in cancer therapy, … in the tumor which thrive in a TGF-β-rich environment. …

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

L Caja, F Dituri, S Mancarella… - International journal of …, 2018 - mdpi.com
… and for the activation of the cancer stroma. TGF-β can control several functions exerted by
most of the cells involved in the fibrotic tissue and in the tumour microenvironment, promoting …

TGF-β signaling: from tissue fibrosis to tumor microenvironment

JYF Chung, MKK Chan, JSF Li, ASW Chan… - International Journal of …, 2021 - mdpi.com
… In cancer, it plays a critical role in tumor microenvironment (TME) for accelerating … of TGF-β
signaling as a critical pathway for generating fibrotic TME, which contains numerous cancer-…

TGFβ signaling in the pancreatic tumor microenvironment

DR Principe, KE Timbers, LG Atia, RM Koch, A Rana - Cancers, 2021 - mdpi.com
… features of PDAC pathobiology, and TGFβ inhibitors are beginning to show … roles of TGFβ
signaling in the pancreatic tumor microenvironment, as well as clinical trials evaluating TGFβ

Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system

T Watabe, K Takahashi, K Pietras… - Seminars in Cancer …, 2023 - Elsevier
Tumor cells evolve in tumor microenvironment composed of … in tumor angiogenesis, which
is a driver of tumor progression … ECs also contribute to tumor progression and metastasis as …

[HTML][HTML] The role of TGF-β in the tumor microenvironment of pancreatic cancer

Q Luo, Z Hu, H Zhao, Y Fan, X Tu, Y Wang, X Liu - Genes & Diseases, 2023 - Elsevier
… Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and … on tumor
microenvironment. The interaction between TGF-β signaling and the tumor microenvironment in …

Tumor microenvironment

B Arneth - Medicina, 2019 - mdpi.com
… of cancer. In addition, nonmalignant cells in the tumor microenvironment play critical roles in
… Aim: This study aims to explore the concept of the tumor microenvironment by conducting a …

Transforming growth factor-β signaling pathway in colorectal cancer and its tumor microenvironment

Y Itatani, K Kawada, Y Sakai - International journal of molecular sciences, 2019 - mdpi.com
… insight into the important roles of TGF-β signaling in the tumor microenvironment. Here we
focus on the TGF-β signaling in CRC and its interaction with the tumor microenvironment. We …

TGFβ signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis

DR Principe, B DeCant, E Mascariñas, EA Wayne… - Cancer research, 2016 - AACR
… While it is well established that TGFβ is a modifier of the tumor microenvironment, the … ,
with most studies focusing on the role of TGFβ on regulating epithelial cells. Previous in vivo …