… The results showed that the optimal number of immunoglobulin binding domains to
induce the largest B-cell response was 5 (95). This observation suggests that B-cell …

… bind peptides stably but non-specifically! The solution of the MHC class II crystal structure, …
The CLIP region was shown to binds to the groove of MHC II molecules in the endoplasmic …

… class II transmembrane domain to drive both M1 and M2 … Major histocompatibility complex
(MHC) class II molecules are … other class II functions such as peptide binding, super-antigen …

… , important residues that are vital for the T-cell receptor (TcR) and major histocompatibility
complex class II (MHC-II… antigen binding domain, whether our predicted superantigen can also …

… is through crosslinked binding to a germline region of a … -binding groove of a class II major
histocompatibility complex (5, 6). … (χ 2 = 5.33), suggesting that the solution structure may adopt …

… the solution-phase HDX-MS data suggest a binding affinity of … observed between superantigens
and the TCR Vβ domain. … region with cognate pMHC could be due to minor structural …

… Superantigens do not need to be processed through antigen-presenting cells but can directly
bind to class II major histocompatibility complex (MHC class II) … region of the TCR β chain ( …

… two binding sites: one in the OB domain for the MHC class II α chain and the other in the β-grasp
domain for … mg/mL SSL7 or SSL11, followed by transfer of the protein solution to a vial of …

… , and as the free proteins in solution, shown by microscale thermophoresis. As for CD28, the
… We have shown that through its β-strand/hinge/α-helix domain, the superantigen binds not …

… binding major histocompatibility complex (MHC) class II on … -fold domain allows for
binding to the invariant MHC class II α… plasma pulled out of solution by binding to SElX2-sepharose, …