… with the aid of class II major histocompatibility complex (MHC) molecules. During presentation,
these SAgs bind to amino acid residues outside the peptide-binding domain [2, 7]. The …

… , and as the free proteins in solution, shown by microscale thermophoresis. As for CD28, the
… We have shown that through its β-strand/hinge/α-helix domain, the superantigen binds not …

… major histocompatibility complex class I and class II proteins have a different chain structure,
the organization of their domains is … Superantigens bind class II MHC molecules as intact …

… Patients with TRBV11-2 expansion shared HLA class I alleles … -2 (Vβ21.3) strongly interact
with the superantigen-like motif … favor instead an exposure to the solution. Thus, the sequence …

… aureus consists of at least 26 different paralogues that function by cross-linking major
histocompatibility complex (MHC) class II molecules with the variable region of the T cell receptor (…

… , they show minimal polymorphism in the Ag-binding domain, and they lack N-glycosylation …
not the Ag-binding groove. Moreover, the manner by which superantigens bind MHC class II …

… of Major Histocompatibility Complex class II, superantigen and T-cell receptor. Superantigens
directly interact with MHC-II … overall structural fold comprising of two major protein domains: …

… domain is responsible for binding to the diverse major … superantigen, can elicit massive T
cell activation through simultaneous binding to major histocompatibility complex (MHC) class II …

… superantigen assists the colonization of S. aureus [4, 5]. TSST-1 of S. aureus binds to major
histocompatibility complex II (MHC II) at a … These toxins (superantigens such as TSST-1) are …

… The Major Histocompatibility Complex (MHC) is called H-2 in … the intracellular domains of
human HLA class II molecules in … of bacterial superantigens [37]. Our results demonstrated that …