The use of computer technologies at the preclinical stage of hepatotoxicity assessment of antiviral drug riamilovir

KD Fedulova, NV Izmozherova… - AIP Conference …, 2020 - pubs.aip.org
Despite the fact that riamilovir is already used in clinical practice for influenza treatment in
the territory of the Russian Federation, it can be used as broad-spectrum potential antiviral
because chemically it is a nucleotide analog. This article provides the analysis of
experimental data from a preclinical investigation of riamilovir's hepatotoxicity. At this stage
of a preclinical study in vivo experiment was used on guinea pigs and computer modeling of
ADMET profile and molecular docking of riamilovir with potential target N-domain HSP90α …
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