Anti-TNF-α therapies for the treatment of Crohn's disease: the past, present and future

M Berns, DW Hommes - Expert opinion on investigational drugs, 2016 - Taylor & Francis
… the overexpression of tumor necrosis factor α (TNF-α), a … A more practical alternative to
intravenous infusions includes … that contribute to the overall therapeutic effects of the biologics. …

Use of anti-TNF drug levels to optimise patient management

K Papamichael, AS Cheifetz - Frontline gastroenterology, 2016 - fg.bmj.com
… -TNF therapy efficacy, safety and cost. However, … Anti-tumour necrosis factor (TNF)
therapies, infliximab, adalimumab, … consequently treatment failure due to infusion reactions.4 ,5 …

Intravenous infusion of human adipose mesenchymal stem cells modifies the host response to lipopolysaccharide in humans: a randomized, single-blind, parallel …

D Perlee, LA van Vught, BP Scicluna, A Maag… - Stem Cells, 2018 - academic.oup.com
… MSCs can exert many different immunomodulatory effects that … Tumor necrosis factor (TNF),
interleukin (IL)-1β, IL-2, IL-4, IL-… use of intravenous infusion of ASCs in the treatment of sepsis …

… vasculature with TNF leads effector T cells to the tumor and enhances therapeutic efficacy of immune checkpoint blockers in combination with adoptive cell therapy

…, V Basso, F Curnis, M Freschi, A Corti, A Mondino… - Clinical Cancer …, 2018 - AACR
several of these antibodies for the treatment of various … of tumor necrosis factor-α (TNF) to
the tumor endothelium with Cys… following day were iv injected into the lateral tail vein with 0.5 × …

Tocilizumab for the treatment of Behçet uveitis that failed interferon alpha and anti-tumor necrosis factor-alpha therapy

H Eser Ozturk, M Oray… - Ocular immunology and …, 2018 - Taylor & Francis
multiple retinal infiltrates in both eyes. The patient was treated with intravenous
methylprednisolone pulse therapy (… resistant to TCZ treatment during the first five infusions and we …

[PDF][PDF] Anti-tumor necrosis factor therapy is not associated with post-operative infection: results from prospective cohort of ulcerative colitis and Crohn's disease …

BL Cohen, P Fleshner, SV Kane, HH Herfarth… - …, 2019 - academia.edu
multi-center prospective study to determine if exposure to anti… comparing the efficacy and
safety of two biologic therapies, … ; or 2) placebo IV infusions/active ADA SC injections (160/80/…

Inflammatory bowel disease and targeted oral anti-TNFα therapy

OR Griffiths, J Landon, RE Coxon, K Morris… - Advances in protein …, 2020 - Elsevier
tumor necrosis factor-alpha (hTNFα) through the use of anti-… generation of ADAs that reduce
treatment efficacy over time. For … therapy would be one that has the effect of intravenous anti-…

Effects of combination therapy with immunomodulators on trough levels and antibodies against tumor necrosis factor antagonists in patients with inflammatory bowel …

Y Qiu, R Mao, B Chen, S Zhang, J Guo, Y He… - Clinical …, 2017 - Elsevier
… Studies investigating the association between clinical efficacy and infusion reactions with
anti-TNF-αSeveral observational studies and randomized controlled trials have examined the …

Safety, tolerability and efficacy of repeated intravenous infusions of KHK4083, a fully human anti-OX40 monoclonal antibody, in Japanese patients with moderate to …

H Nakagawa, H Iizuka, O Nemoto, M Shimabe… - Journal of …, 2020 - Elsevier
… OX40, a member of the tumor necrosis factor receptor (TNFR) … to severe AD by assessing
treatment-emergent adverse events (… reactions of mild or moderate severity occurred in several

Association of preoperative antitumor necrosis factor therapy with adverse postoperative outcomes in patients undergoing abdominal surgery for ulcerative colitis

AS Kulaylat, AN Kulaylat, EW Schaefer, A Tinsley… - JAMA …, 2017 - jamanetwork.com
… for the treatment of UC in 2005 and was followed several years … to having an effect on
restorative procedures, anti-TNF … requires in-office intravenous infusion, unlike the subcutaneous …