Background and objectives: Thyroid hormone has an important role in the cardio¬ vascular homeostasis. Small variations of the thyroid hormone within the physiological range have been linked to adverse cardiovascular prognosis. Several studies have reported changes in thyroid status in “Euthyroid sick syndrome” patients admitted with acute coronary syndrome. Therefore, this study was conducted to analyze the thyroid hormone profile in patients with ACS and to compare it between STEMI and NSTEMI/UA groups.

Materials and methods: A total of 100 patients were enrolled n this study and were divided into two groups as STEMI and NSTEMI/UA group. Thyroid function tests (fT3, fT4, TSH) were done by ELISA method within 24 hours of admission. The data were analyzed by SPSS version

17 software.

Results: Euthyroid Sick Syndrome was observed in 60%, subclinical hypothyroidism in 28% and subclinical hyperthyroidism in 8% of patients with abnormal thyroid hormone profile. A higher prevalence of abnormal thyroid hormone profile was seen in elderly age group> 60 years (56%) followed by age group 40-60 years (36%) and 20-40 years (8%). A statistically higher prevalence of abnormal thyroid hormone profile was seen in STEMI group (72%) as compared to NSTEMI/UA group (28%). However, the difference in prevalence of ESS was not statistically significant between STEMI and NSTEMI/UA group.

Conclusion: The overall prevalence of abnormal thyroid hormone profile was statistically significant in the STEMI group, the prevalence of ESS did not show any statistically significant difference in STEMI and NSTEMI/UA groups.