… of Schu S4 to modulate host cell death during infection, we … S4 delays macrophage death
in a TolC-dependent manner. … the TolC-dependent delay in host cell death is required for F. …

… tularensis delays host cell death until late time points (~24 h pi), at a stage where the … Our
results suggest that TolC-dependent activity counteracts early TLR2-MYD88 signaling, while …

… tularensis SchuS4 is only partially attenuated for virulence in mice. TolC is also required
for … , and apoptotic cell death (20, 21). However, the induction of apoptosis in neutrophils is …

… cell death might trap bacteria inside host cell remnants, leading to their elimination by
efferocytosis (removal of dead cells… in Francisella genomes, including the TolC-dependent efflux …

… other forms of cell death observed with attenuated strains. For … in cells infected with attenuated
strains of Francisella, we … However, in contrast to the findings for SchuS4-infected cells…

… regulatory factors or TolC-dependent secretion. … envelope is unusual, it is also of interest
that BLPs of other bacteria enhance rather than impair host cell death. For example, a 19-kDa …

… Specifically, we wished to determine whether opsonization of strain SCHU S4 with
complement influenced cell death induction in infected primary human monocyte-derived …

… Francisella tularensis subspecies tularensis (Ft), a … of tularemia, an acute and sometimes
fatal disease. A consequence of infection of host cells by Ft is the induction of host cell death (…

… The DNA-sensing inflammasome component AIM2 has been identified as a critical mediator
of inflammasome activation and cell death (16, 17). Interestingly, it has recently been shown …

… , Francisella novicida and Francisella tularensis live vaccine strain lyse in the host cytosol …
caspase-1 processing and cell death are fully deficient in the latter cells. The same phenotype …