… Here, we summarize how molecular systems fine-tune hypoxia-inducible transcription with
… domain in HIF1/2α, which is mediated by the asparaginyl oxygenase FIH1 (factor inhibitory …

… are the hypoxia-inducible factor (HIF) family of transcription factors. … transactivation domain
(CTAD) of HIF-1α and HIF-2α, … chromatin domains, which modulate gene transcription [61]. …

… transactivation domain (N-TAD) located in the ODD domain, … residue that is hydroxylated by
factor inhibiting HIF-1 (FIH-1) is … later found to be an alternative spliced transcript of the Hif-3α …

… transcription factor hypoxia-inducible factor-1α (HIF-1α). In hypoxic cells, HIF-1α acts as a
transcription factor … HIF-1α is a chief transcription factor that modulates low O 2 and nutritional …

… The modulation of HIF‑1α can reduce sorafenib … the transcription factor hypoxia-inducible
factor (HIF) enables cancer cells to adapt to the hypoxic environment via the transactivation of …

… transactivating domain of HIF1α and HIF2α under normoxia to prevent recruitment of the
transcription … modulating the activity of eukaryotic elongation factor 2 (eEF2) kinase (eEF2K), an …

… of the most important transcription factors, hypoxia inducible factor-1 (… In addition, two
transactivation domains namely the N-… In fact, PHDs and FIH modulate the activity of IKKβ through …

… overexpression of hypoxia-inducible transcription factors and the … Drugs and inhibitors
modulate diverse aspects of HIF-1α … , or HIF-1α synthesis, degradation, or transactivation. Color …

… protease degradation pathways, which are inhibited during hypoxia (8,10). HIF-1α is a
hypoxia inducible transcription factor that contains two transactivation domains (C-TAD and N-…

… signalling modulates the temporal expression of Hif-1α protein… transactivation of circadian
core clock genes by binding of Hif-… -1α protein, and although inhibition of p38 with the inhibitor …