… the transactivation of target genes by HIFs. In conditions of hypoxia, the hydroxylase activity
of the PHDs and FIH is inhibited, … co-activators to transactivate the transcription of hypoxia-…

… stabilization of the transcription factors, hypoxia-inducible factor-1 … Among N-TAD and C-TAD
lies an inhibitory domain, the … The second major mechanism that modulates HIF-2α activity …

… is the major transactivation domain responsible for HIF-1α or … with various auxiliary transcription
factors such as p300/CBP; … and metastasis by modulating the expression of vascular cell …

… transactivation domain (C-TAD) and for the presence of a unique leucine zipper (LZIP) …
the transcription of target genes encoding for proteins serving to down-modulate mitochondrial …

… hydroxylase domain-containing protein (PHD) and factor inhibiting HIF… of hypoxia-inducible
factor (HIF), which is a key transcription … in repressed transactivation. PHD prolyl hydroxylase …

… Hypoxia-inducible factors (HIFs) are the key transcription … involving the modulation of HIF
pathways will be discussed. … C terminal transactivation domain to block its binding with the CH1 …

… transcriptional activation domain of hypoxia-inducible factor alpha … are transcription factors
named hypoxia-inducible factors (… (2,4,5) HIF is an α,β-heterodimeric transcription factor which …

… the expression of the HIF-1α transcription factor in TNBC. We also … inhibition of HDAC reduced
the expression level of HIF-1α protein… P300/CBP has acetylase activity that modulates the …

… -PAS) transcription factor superfamily and consist … inhibiting mitochondrial reactive oxygen
species (ROS) 97 . Furthermore, HIF1α and HIF2α influence ROS production via modulation …

… -terminal transactivation domain (CAD), leading to inhibition of … These transcription factors
are differentially regulated by … that an agent that modulates the activity of HIF-1α can be used …