… and clinical signi cance of the steroidogenic factor-1(SF-1) in … CpG islands in the promoter
region of genes has become a research hotspot[11, 12]. Tumor-related gene hypomethylation …

… of cytosines in a CpG island located in the promoter … ; the CpG island in this case would be
'hypomethylated' (37). The methylation of promoters inhibits their recognition by transcription …

… inhibits transcription by preventing transcription factors from … In conclusion, the
hypomethylation of CpG island in ESR2 … III is associated with steroidogenic factor 1 expression in …

… DNA methylation of the 5′ CpG island was analysed using … to the steroidogenic factor
1 (SF-1) response element (5′-… , the sgVtg CpG island was found to be hypomethylated (with …

… Hypermethylation of promoter and transcription start site (TSS) are … hypomethylated regions
were observed in our comparisons. Abnormal methylations in regions relative to CpG islands …

… estrogen-induced genes (trefoil factor 1, TFF1; growth regulation by … ), and CpG islands in
the promoter regions of ESR1 (promoter B) and ESR2 [up to 300 bp upstream of transcriptional …

… PR-B is considered as a dominant transcriptional activator of progesterone… hypermethylation
of this CpG island is present in SF-1-negative endometrial stromal cells, while the most CpG …

… ), low DNA methylation (5 mC) and a CpG island at the bottom. … be responsible for ESR1
promoter hypermethylation in PR-… In many cases, the transcriptional regulation of steroid target …

… Taken together, our studies illustrate how CpG island hypermethylation defines an ACC
molecular class and exposes a tissue-specific therapeutic vulnerability centered on the …

… -associated CpG hypermethylation and hypomethylation are … some CpG islands surrounding
the specific gene transcription … 5 group A member 1, also known as steroidogenic factor-1 (…