[HTML][HTML] Rac1/β-catenin signalling pathway contributes to trophoblast cell invasion by targeting snail and MMP9

M Fan, Y Xu, F Hong, X Gao, G Xin, H Hong… - Cellular Physiology and …, 2016 - karger.com
… -8/SVneo cells with a shRNA Rac1 vector and the β-catenin inhibitor … The literature also
suggests that Snail-induced migration and … transforming growth factor-β1-mediated epithelial cell

[HTML][HTML] Transforming growth factor β1 promotes invasion of human JEG-3 trophoblast cells via TGF-β/Smad3 signaling pathway

Z Huang, S Li, W Fan, Q Ma - Oncotarget, 2017 - ncbi.nlm.nih.gov
cell invasion. Silencing Smad3, not Smad2, inhibited the TGF-β1-induced cell invasion in
JEG-3 cells. … role of Smad3 in TGF-β1-induced JEG-3 cell invasion. Therefore, targeting Smad3 …

TGF-β1 Inhibits Human Trophoblast Cell Invasion by Upregulating Connective Tissue Growth Factor Expression

JC Cheng, HM Chang, PCK Leung - Endocrinology, 2017 - academic.oup.com
… regulation of trophoblast cell invasion remains unclear. Transforming growth factor-β1 (TGF-…
We show that both SMAD2 and SMAD3 are involved in TGF-β1–induced CTGF expression. …

TGF-β1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2

Y Yi, JC Cheng, C Klausen, PCK Leung - Placenta, 2018 - Elsevier
… and transforming growth factor-β1 (TGF-β1) have been shown to inhibit human trophoblast
cell invasion. … suggest that rapid induction of COX-2 by TGF-β1 may suppress trophoblast cell

Epithelial-mesenchymal transition during extravillous trophoblast differentiation

J E. Davies, J Pollheimer, HEJ Yong… - … & migration, 2016 - Taylor & Francis
… For example, transforming growth factor β (TGFβ) plays … and FGR through inhibition of
trophoblast differentiation into an … cancer cells induces cell migration, invasion, and metastasis. J …

Regulation of placentation by the transforming growth factor beta superfamily

EA Adu-Gyamfi, YB Ding, YX Wang - Biology of Reproduction, 2020 - academic.oup.com
… by up-regulating SNAIL-mediated expression and activity of … A, B, and AB facilitates human
trophoblast cell invasion by up-… inhibits trophoblast proliferation by inducing G1 cell cycle …

GATA3 and TGF-β in normal placenta and pre-eclampsia

A Perna, E Hay, A Lucariello, B Scala, P De Blasiis… - Tissue and Cell, 2024 - Elsevier
… Also transforming growth factor beta (TGF-β) plays a … In pre-eclampsia TGF-β inhibits
trophoblast cell invasion during the … epithelial markers and induce mesenchymal markers. These …

[HTML][HTML] GDF15 deficiency hinders human trophoblast invasion to mediate pregnancy loss through downregulating Smad1/5 phosphorylation

YT Zeng, WF Liu, PS Zheng, S Li - Iscience, 2023 - cell.com
… , and anti-Mullerian hormone (AMH) belong to the transforming growth factor (TGF-β)
family. The TGF-… TGF-β1 was proved to inhibit trophoblast cell invasion by inducing Snail-mediated

Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta

S Haider, AI Lackner, B Dietrich… - Proceedings of the …, 2022 - National Acad Sciences
… Inspection of the different trophoblast models revealed that TGF-β inhibition altered cellular
… be critical for the induction of human trophectodermal stem cells from naive pluripotent stem …

[HTML][HTML] The role of TGF-β during pregnancy and pregnancy complications

B Wen, H Liao, W Lin, Z Li, X Ma, Q Xu… - International Journal of …, 2023 - mdpi.com
Transforming growth factor beta (TGF-β) serves as a … that TGF-β also inhibits trophoblast cell
invasion during the first … promotion or inhibition of decidualization, as well as the induction of …