Transient receptor potential vanilloid 4–expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch
Background Chronic itch is a highly debilitating symptom that underlies many medical
disorders with no universally effective treatments. Although unique neuronal signaling
cascades in the sensory ganglia and spinal cord have been shown to critically promote the
pathogenesis of chronic itch, the role of skin-associated cells remains poorly understood.
Objective We sought to examine the cutaneous mechanisms underlying transient receptor
potential vanilloid 4 (TRPV4)–mediated allergic and nonallergic chronic itch. Methods …
disorders with no universally effective treatments. Although unique neuronal signaling
cascades in the sensory ganglia and spinal cord have been shown to critically promote the
pathogenesis of chronic itch, the role of skin-associated cells remains poorly understood.
Objective We sought to examine the cutaneous mechanisms underlying transient receptor
potential vanilloid 4 (TRPV4)–mediated allergic and nonallergic chronic itch. Methods …