… gene activity score (GAS) is often used to translate the DPYD genotype into a DPD phenotype
to describe DPD activity … This translation of DPYD genotypes to their functional activity is …

… , focused overview of the use of DPYD genotyping and DPD phenotyping with relevance to
… in the DPD enzyme activity. A DPYD genotype test is cheap and reliable, and the results do …

… variants have been strongly correlated with in vitro DPD activity; however, this relationship
… A gene-activity score has also been proposed to translate genotype to phenotype and …

… DPYD genotyping with an upfront dose adjustment in DPD … The HuGE risk translator [33]
is an online tool to calculate test … Phenotyping tests measuring DPD enzyme activity directly …

… gene activity score based on DPYD genotype, we recommend to determine the DPD activity
… for enabling local translation of assay results into the predicted phenotype (in this case the …

… in DPD phenotyping and DPYD expression within non-… -described DPYD variants result in
pathogenic DPD deficiency … on the DPYD genotypic and DPD phenotypic characteristics of the …

… the initial dose based on phenotype and genotype or avoid … absent or greatly decreased
DPD activity results in uracil and … of intron 14 leads to translation skipping exon 14, resulting in …

… In patients carrying multiple DPYD variants, we recommend that a DPD phenotyping assay
… calculated DPD activity using genotyping or phenotyping. These differences would result in …

… DPD activity comprise: DPYD*2A (rs3918290) and DPYD*13 … for the translation of pre-emptive
DPYD genotyping in clinical … cumulative drug exposure for the phenotypic manifestations. …

… of genetic variants in DPYD and their consequences for DPD … A significant drawback of the
genotyping approach to identify … termination of translation and a nonfunctional DPD protein …