[HTML][HTML] Translational block in stroke: a constructive and “out-of-the-box” reappraisal
A Lourbopoulos, I Mourouzis, C Xinaris… - Frontiers in …, 2021 - frontiersin.org
Why can we still not translate preclinical research to clinical treatments for acute strokes?
Despite> 1000 successful preclinical studies, drugs, and concepts for acute stroke, only two
have reached clinical translation. This is the translational block. Yet, we continue to routinely
model strokes using almost the same concepts we have used for over 30 years.
Methodological improvements and criteria from the last decade have shed some light but
have not solved the problem. In this conceptual analysis, we review the current status and …
Despite> 1000 successful preclinical studies, drugs, and concepts for acute stroke, only two
have reached clinical translation. This is the translational block. Yet, we continue to routinely
model strokes using almost the same concepts we have used for over 30 years.
Methodological improvements and criteria from the last decade have shed some light but
have not solved the problem. In this conceptual analysis, we review the current status and …
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