… our research group evaluated the trypanocidal activity of a series of … of action involved in the
cell death of this parasite. … and depolarization of the mitochondrial membrane in the parasites…

… of a few enzymes involved with oxidative stress responses) … The cascade of events triggered
by the activation of proPO by … a shift from glycolysis to mitochondrial respiration as we move …

… It primarily involves the blockage of nucleic acid synthesis through … It inhibits DNA synthesis,
modifies the mitochondrial … oxidation of the erythrocytes generating oxidative stress due …

… as hypoxia, oxidative stress, and DNA damage, leading to the … ROS accumulation and lipid
peroxidation, such as elatol in T. … findings, these derivatives caused mitochondrial membrane …

… trypanocidal action of (−)-elatol involves the induction of the autophagic and apoptotic death
pathways triggered … This includes remarkable swelling of mitochondrion, destabilization of …

… mechanisms are related to the intrinsic pathway and involve participation of mitochondria
or … The imbalance of Ca 2+ influx in the mitochondrion triggers oxidative stress in …

… The typical treatments for leishmaniasis involve pentavalent … resulting oxidative stress
is associated with mitochondrial … with sesquiterpene (−)-elatol caused membrane rigidity [34]. …

… Similar to our findings, these derivatives caused mitochondrial membrane depolarization,
an … Trypanocidal action of (-)-elatol involves an oxidative stress triggered by mitochondria …

… by cells under conditions of oxidative stress, which has been … Mitochondria are a major
source of reactive oxygen species (… changes are related to cell damage caused by HNE, we …

… Silvestrol and elatol both show no activity against mTORC1 … We noted, however, that
elatol in contrast to silvestrol induced … on serine 51 during an integrated stress response (ISR)(34). …