[PDF][PDF] Research Article Eupomatenoid-5 Isolated from Leaves of Piper regnellii Induces Apoptosis in Leishmania amazonensis
FP Garcia, D Lazarin-Bidóia, T Ueda-Nakamura… - academia.edu
… We initially focused on investigating mitochondrial alterations … Our data suggest that
eupomatenoid-5 induces oxidative … of the trypanocidal action of eupomatenoid-5: confirmation of …
eupomatenoid-5 induces oxidative … of the trypanocidal action of eupomatenoid-5: confirmation of …
[HTML][HTML] Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: Mitochondrion as a strategic target
D Lazarin-Bidóia, FP Garcia… - Memórias do Instituto …, 2022 - SciELO Brasil
… Further evidence of the trypanocidal action of eupomatenoid-5: confirmation of … trypanocidal
action of eupomatenoid-5 could be associated with mitochondrial dysfunction and oxidative …
action of eupomatenoid-5 could be associated with mitochondrial dysfunction and oxidative …
Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes
C Fonseca-Berzal, CF DA SILVA, RFS Menna-Barreto… - Parasitology, 2016 - cambridge.org
… and mitochondrial machinery as part of the mode of action of … involved in the trypanocidal
activity of these compounds, studies … by the neolignan dihydrobenzofuranic eupomatenoid-5 on …
activity of these compounds, studies … by the neolignan dihydrobenzofuranic eupomatenoid-5 on …
… type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell …
KD Rodríguez-Hernández, I Martínez… - Bioorganic …, 2020 - Elsevier
… We decided to investigate possible oxidative damage caused by mammea A/BA in the
parasites. … The present study found that the trypanocidal effect of mammea A/BA appears to be a …
parasites. … The present study found that the trypanocidal effect of mammea A/BA appears to be a …
Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages
SS Grecco, TA Costa-Silva, G Jerz, FS de Sousa… - Chemico-biological …, 2017 - Elsevier
… action demonstrated that neolignan 4 caused substantial alteration of the plasma membrane
permeability, together with mitochondrial dysfunctions … for other trypanocidal compounds [16…
permeability, together with mitochondrial dysfunctions … for other trypanocidal compounds [16…
Anti-Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure
A Pinto-Martinez, V Hernández-Rodríguez… - Experimental …, 2018 - Elsevier
… trypanocidal action of eupomatenoid-5 have shown a marked involvement of the mitochondria
… It was shown that eupomatenoid-5 induces an oxidative stress in the three main forms of …
… It was shown that eupomatenoid-5 induces an oxidative stress in the three main forms of …
Dibenzylideneacetones are potent trypanocidal compounds that affect the Trypanosoma cruzi redox system
D Lazarin-Bidóia, VC Desoti, SC Martins… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
… another trypanocidal compound (38). Increases in oxidant species induce mitochondrial
dysfunction, … We believe that the increase in ROS/RNS is a cause of mitochondrial dysfunction. …
dysfunction, … We believe that the increase in ROS/RNS is a cause of mitochondrial dysfunction. …
Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria
TR Alexandre, ML Lima, MK Galuppo… - Journal of Venomous …, 2017 - SciELO Brasil
… Mitochondrial dysfunction promoted by ergosterol was … Further evidence of the trypanocidal
action of eupomatenoid-5: … Therefore, we suggest that oxidative stress may not be …
action of eupomatenoid-5: … Therefore, we suggest that oxidative stress may not be …
The antidepressant clomipramine induces programmed cell death in Leishmania amazonensis through a mitochondrial pathway
JH da Silva Rodrigues, N Miranda, H Volpato… - Parasitology …, 2019 - Springer
… of action, clomipramine led parasites do mitochondrial … induced strong oxidative stress in the
parasites. The … of psychiatric disorders, including obsessive-compulsive disorder. It presents …
parasites. The … of psychiatric disorders, including obsessive-compulsive disorder. It presents …
[HTML][HTML] Ultrastructural and physiological changes induced by different stress conditions on the human parasite Trypanosoma cruzi
D Pérez-Morales, KDR Hernández, I Martínez… - Cell Stress and …, 2017 - Elsevier
… As a first approach, we evaluated the effect of acid, nutritional, oxidative, and heat stress on
… as a prominent mitochondrial swelling accompanied by a loss in density of the mitochondrial …
… as a prominent mitochondrial swelling accompanied by a loss in density of the mitochondrial …