… differential sensitivity to drugs is critical to more efficient therapies and control of tumour
growth… Chemotherapeutic agents target bulk cancer cells with normal levels of drug efflux, …

… yet it can be diagnosed and treated early by focusing on potential therapeutic targets and
establishing promising diagnostic and prognostic markers. As per IARC (International Agency …

… differentiation of CSCs. When the cells are committed to differentiation, they cannot initiate
tumor growth … of CD51 could be a therapeutic target for restricting progression of prostate …

… on cancer cell plasticity and its impact on cancer progression … to target slow-cycling, dormant,
dedifferentiated cancer cells … and differentiation inhibition induced by cancer progression …

… cancer growth, these cancer stem cells seem to be a likely target for novel strategies for
prostate cancer therapy. … prostate cancer cells caused growth inhibition and rapid apoptosis in …

… functions and are closely related to tumor progression. It has been shown that protumor
macrophages that have differentiated through interaction with tumor cells are involved in stem …

… differentiation in the myeloid malignancies for therapeutic … relieving differentiation blockade
with anti-neoplastic therapies … treatments that explicitly target cellular differentiation. Moving …

… be involved in CAF differentiation upon TGFβ exposure, increasing tumor growth and ECM
… Interestingly, the use of an inhibitor of CSF-1 receptor; the JNJ-40346527, to target the tumor-…

… related with cancer progression, resistance to therapy, and … tumor growth is to measure
the tumor growth rate (TGR), defined as an estimation of the increase/decrease of the tumor …

… tumor progression and augments chemosensitivity. While this therapeutic strategy is already
being used for treatment of … from that used for cancer treatment since the goal for this latter is …