[PDF][PDF] Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress

J Tsoi, L Robert, K Paraiso, C Galvan, KM Sheu, J Lay… - Cancer cell, 2018 - cell.com
therapeutic approach to target the differentiation plasticity of melanoma cells to increase the
efficacy of targeted and immune therapies. … during treatment and upon disease progression

Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer

N Jyotsana, M Heuser - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
differential expression of splice variants that are frequently linked to cancer progression,
metastasis and therapy … of alternative splicing events in cancer progression is known for few of …

Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
… during the cancer progression and have the potential to be targeted for anticancer therapy.
… signals mediating crosstalk of CAFs with cancer cells and its related targets or trials. Further, …

Tumor microenvironment components: Allies of cancer progression

PIR Franco, AP Rodrigues, LB de Menezes… - … -Research and Practice, 2020 - Elsevier
targets in the study of tumor biology and oncology therapies [… The stem cell differentiation
mechanism is highly controlled … to tumor progression enable specific therapeutic strategies for …

Tumor-associated macrophages: an accomplice in solid tumor progression

Y Chen, Y Song, W Du, L Gong, H Chang… - Journal of biomedical …, 2019 - Springer
… can be used as therapeutic targets of solid tumor in clinics. The therapeutic strategies include
… The differential contributions of iTreg and nTreg to the immunosuppressive properties of …

… , radionecrosis, inflammation or true tumor progression? Challenges associated with glioblastoma response assessment in an evolving therapeutic landscape

BM Ellingson, C Chung, WB Pope, JL Boxerman… - Journal of neuro …, 2017 - Springer
tumor response to therapy with the goal of both understanding biological changes within the
… promising methods for differentiation of tumor progression from recurrent disease based on …

Tumor microenvironment as a therapeutic target in cancer

Y Xiao, D Yu - Pharmacology & therapeutics, 2021 - Elsevier
… to play critical roles in tumor progression and therapeutic responses, attention has been …
exclusive categories marked by discrete activation or differentiation status (polarization), has …

Tumor-derived exosomes and their role in cancer progression

TL Whiteside - Advances in clinical chemistry, 2016 - Elsevier
therapy suggest that tumor-derived exosomes are critical … changes in target cells that favor
tumor progression. Numerous … tumor stroma, driving neovascularization, cell differentiation

Transforming growth factor-β: A therapeutic target for cancer

S Haque, JC Morris - Human vaccines & immunotherapeutics, 2017 - Taylor & Francis
cancer progression. In later stages TGF-β plays a key role in promoting tumor progression
… and endochondral tissue highlighting its role in growth and tissue differentiation. TGF-β2 is …

[HTML][HTML] Metabolic cooperation and competition in the tumor microenvironment: implications for therapy

S Gupta, A Roy, BS Dwarakanath - Frontiers in oncology, 2017 - frontiersin.org
… for identifying suitable targets for developing newer therapeutic approaches. … decide
the fate of the tumor growth by affecting the functions and differentiation of various subsets of …