KDR amplification is associated with VEGF-induced activation of the mTOR and invasion pathways but does not predict clinical benefit to the VEGFR TKI vandetanib

MB Nilsson, U Giri, J Gudikote, X Tang, W Lu… - Clinical Cancer …, 2016 - AACR
… Calu-1 cells with 50 ng/mL of VEGF or hepatocyte growth factor (… in modulating HIF1α levels
under normoxic conditions has … to increase HIF1α levels in a hypoxia-independent, cell type–…

[HTML][HTML] A receptor-antibody hybrid hampering MET-driven metastatic spread

C Modica, C Basilico, C Chiriaco, N Borrelli… - … & Clinical Cancer …, 2021 - Springer
… and its ligand Hepatocyte Growth Factor (HGF) are at the core of the invasive-metastatic
behavior. … in preventing spreading of pancreatic cancer cells from orthotopic primary tumors. The …

[HTML][HTML] Soluble compounds released by hypoxic stroma confer invasive properties to pancreatic ductal adenocarcinoma

D Liu, A Steins, R Klaassen, AP van der Zalm… - Biomedicines, 2020 - mdpi.com
hypoxia and stroma interact to contribute to invasive growth in … that hypoxia is related with
stroma activation, hypoxia pathwaygrowth of pancreatic cancer cells and that among these, …

[HTML][HTML] The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells

X Zhang, M Zhang, H Sun, X Wang, X Wang… - Journal of Advanced …, 2024 - Elsevier
… Furthermore, SNAIL expression in tumor stromal myofibroblasts … hepatocyte growth factor
(HGF) promotes proliferation, migration, and invasion of GC cells with unamplified MET through

[HTML][HTML] MET-targeted therapy for gastric cancer: the importance of a biomarker-based strategy

H Kawakami, I Okamoto - Gastric cancer, 2016 - Springer
… , survival, migration, and invasion as well as tumor … , hepatocyte growth factor (HGF), with
the latter pathway having … antagonism of ligand–receptor interaction. The evidence implicating …

[PDF][PDF] LC3C-mediated autophagy selectively regulates the Met RTK and HGF-stimulated migration and invasion

ES Bell, PP Coelho, CDH Ratcliffe, CV Rajadurai… - Cell reports, 2019 - cell.com
… The hepatocyte growth factor (HGF) and its receptor, the Met … RTK can occur through a
Met/LC3C interaction that acts to … could also occur in hypoxic regions of tumors, even in the …

Emerging kinase inhibitors for the treatment of pancreatic ductal adenocarcinoma

U Rudloff - Expert opinion on emerging drugs, 2022 - Taylor & Francis
… for new pancreas cancer cases and pancreas cancer-related … the ECM into the cytoplasm
mediating cell plasticity, cell invasion, … cancer cells further upregulate in response to hypoxia, …

[HTML][HTML] Mechanisms of peritoneal dissemination in gastric cancer

F Sun, M Feng, W Guan - Oncology letters, 2017 - spandidos-publications.com
cancer cells to promote cell invasion and migration. c-MET, also known as hepatocyte
growth … Additionally, milky spots also serves as a hypoxic niche, which enhances the self-renewing …

[HTML][HTML] Long noncoding competing endogenous RNA networks in pancreatic cancer

G Xiong, S Pan, J Jin, X Wang, R He, F Peng… - Frontiers in …, 2021 - frontiersin.org
invasion of PC (10). Accumulating studies have revealed that the disorders of various signaling
pathways mediate changes in the tumor stromal cells… miR-142/HIF-1α axis under hypoxic

[HTML][HTML] Molecular targets, therapeutic agents and multitasking nanoparticles to deal with cancer stem cells: A narrative review

A Doustmihan, M Fathi, MA Mazloomi, A Salemi… - Journal of Controlled …, 2023 - Elsevier
… are increasing our understanding of the pathways and factors … conditions such as low oxygen
levels (hypoxia). They also … level, and these cells exhibit strong invasiveness and motility […