… Therefore, this review substantiates the role of UPS in the brain signaling and neuronal … ,
and proteasomal dysfunction. Ubiquitin proteasome system (UPS) dysfunction is central to all …

… This suggests that dysfunction of the UPS in … in normal brain function and pathogenesis
of neurodegenerative … By enriching our understanding of protein degradation, we can begin …

… of such regulatory influences on neuronal function. For example, it … functional link between
UPS and mitochondrial dysfunction, … protein degradation by the UPS under these conditions. …

… Notably, UPS-dependent protein degradation and turnover represent a major mechanism
driving synapse remodeling and plasticity, and are involved in a number of brain diseases [7,8,…

… transport and neuronal function 8. Protein degradation is primarily performed by proteasomes
in … lead to pleiotropic effects, such as neurodegeneration, synaptic dysfunction and neuron …

… mechanisms of intracellular protein degradation: the ubiquitin-proteasome system (UPS) …
reverses mitochondrial dysfunction and neuronal damage induced by proteasome inhibitors …

… stress on protein and the proteasomal dysfunction. Similarly, Saito et al. showed that HRD1
… protein degradation by the ubiquitin/proteasome pathway is essential for neuronal survival […

… its aggregation propensity resulting in cytotoxicity and molecular dysfunction in neuronal
cells. This translates into motor disabilities, cognitive decline, and psychiatric problems [113]. …

… in the brain, suggesting severe impairment in cellular protein degradation pathways [6, 7].
Typically… have long been considered neuron-autonomous disorders, an important role for non-…

… motor neurons (MNs). Since the identification of the first ALS mutation in 1993, more than 40
genes have been associated with the disorder… role played by autophagy dysfunctions in the …