[HTML][HTML] How do adenosine A2A receptors regulate motor function?

A Mori - Parkinsonism & related disorders, 2020 - Elsevier
… , along with its ultrastructural localization in critical areas/… As a result, many new questions
have arisen requiring … PD suggests that large numbers of adenosine A 2A receptors expressed …

Adenosine A2A receptors control synaptic remodeling in the adult brain

X Xu, RO Beleza, FQ Gonçalves, S Valbuena… - Scientific Reports, 2022 - nature.com
… , we are displaying the site without styles and JavaScript. … abnormally to the outer two-thirds
of granule cell layer 38,40 . … Altogether, these results indicate that the adenosine triggering …

Structure and function of adenosine receptor heteromers

R Franco, A Cordomí, C Llinas del Torrent… - Cellular and Molecular …, 2021 - Springer
… X-ray crystallography or cryogenic electron microscopy (cryo-EM)… at the extracellular orthosteric
binding site triggers local structural … The existence of these interfaces implies two internal …

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo

X Morató, R Luján, M López-Cano, J Gandía… - Scientific Reports, 2017 - nature.com
… regional and overlapping localization of these two receptors in the … by means of immunogold
electron microscopy. GPR37 … Overall, our results suggested that GPR37 may modulate A …

[PDF][PDF] Adenosine receptors in mesenteric arteries adventitia: evidence for a nuclear location

RRM de Oliveira - 2018 - repositorio-aberto.up.pt
… employing confocal microscopy suggested an overlay pattern of … of adenosine receptors is
involved in multiple cellular … studied using high-resolution electron microscopy that permit the …

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

J García-Nafría, Y Lee, X Bai, B Carpenter, CG Tate - elife, 2018 - elifesciences.org
… We therefore do not have an absolutely identical comparison of the two detectors. … the
heterotrimeric G protein, suggests that this region is more dynamic than suggested from the X-ray …

Adenosine A1 and A2A receptors in the brain: current research and their role in neurodegeneration

J Stockwell, E Jakova, FS Cayabyab - Molecules, 2017 - mdpi.com
… into the function of these two receptors in the brain and their role … suggested that a novel
mechanism that contributes to the regulation of the surface localization of adenosine receptors

Expression of Adenosine A2B Receptor and Adenosine Deaminase in Rabbit Gastric Mucosa ECL Cells

RM Arin, AI Vallejo, Y Rueda, O Fresnedo, B Ochoa - Molecules, 2017 - mdpi.com
… As shown in the dot plot of the flow cytometry, two cellular … of one or two binding site
populations using GraphPad … Collectively, our findings indicate that rabbit gastric ECL cells …

International union of basic and clinical pharmacology. CXII: adenosine receptors: a further update

AP IJzerman, KA Jacobson, CE Müller… - Pharmacological …, 2022 - ASPET
adenosine receptors, to examine a multitude of receptor structures and novel ligands, to
gauge new pharmacology, and to evaluate clinical trials with adenosine receptorMany clinical …

Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives

D Guidolin, M Marcoli, C Tortorella, G Maura… - Progress in Molecular …, 2020 - Elsevier
… of agonists of the two receptors on receptor trafficking, including cell surface expression and
suggesting MV as the carriers of A 2A and D 2 receptors. Transmission electron microscopy