Ghrelin knockout mice display defective skeletal muscle regeneration and impaired satellite cell self-renewal

E Angelino, S Reano, A Bollo, M Ferrara, M De Feudis… - Endocrine, 2018 - Springer
… the ghrelin gene, ie, acylated ghrelin (AG), unacylated ghrelin … Consistently, muscle
regeneration after CTX injury improves … skeletal muscle; in particular, they promote skeletal muscle

Ghrelin, microRNAs, and critical limb ischemia: hungering for a novel treatment option

JPH Neale, JT Pearson, R Katare… - Frontiers in …, 2017 - frontiersin.org
… , promote muscle regeneration, and reduce oxidative stress … to induce skeletal muscle
regeneration through increased … AG may improve the skeletal muscle recovery following CLI, but …

Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; clinical relevance to peripheral artery disease

JPH Neale, JT Pearson, KN Thomas, H Tsuchimochi… - Scientific reports, 2020 - nature.com
… to the hindlimb microvasculature following prolonged ischemiaghrelin promoted skeletal
muscle regeneration via the modulation of miRNAs-221 & -222 28 , and protected the hindlimb

Ghrelin promotes functional angiogenesis in a mouse model of critical limb ischemia through activation of proangiogenic microRNAs

R Katare, S Rawal, PE Munasinghe… - …, 2016 - academic.oup.com
Skeletal muscle fibrosis was analyzed by Sirius red staining using established protocol,
followed … showed the ability of unacylated ghrelin in regeneration of the skeletal muscle, and few …

Unacylated ghrelin enhances satellite cell function and relieves the dystrophic phenotype in duchenne muscular dystrophy mdx model

S Reano, E Angelino, M Ferrara, V Malacarne… - Stem Cells, 2017 - academic.oup.com
… of skeletal muscle regeneration induced by hindlimb ischemia [10, … UnAG ability to enhance
skeletal muscle regeneration, we … for ghrelin upregulation observed in muscles after injury. …

[HTML][HTML] Effect of unacylated ghrelin on peripheral nerve regeneration

G Ronchi, P Tos, E Angelino, L Muratori… - European Journal of …, 2021 - ncbi.nlm.nih.gov
… Moreover, UnAG promotes skeletal muscle regeneration in … of UnAG in promoting peripheral
nerve regeneration after two … weight, fiber cross-sectional area distribution and hindlimb

Unacylated ghrelin reduces skeletal muscle reactive oxygen species generation and inflammation and prevents high-fat diet–induced hyperglycemia and whole-body …

G Gortan Cappellari, M Zanetti, A Semolic, P Vinci… - Diabetes, 2016 - Am Diabetes Assoc
muscle ROS production and inflammation and enhances … by using Student t test or one-way
ANOVA followed by … (35) and ischemia-induced skeletal muscle regeneration (15). On the …

[HTML][HTML] Both ghrelin deletion and unacylated ghrelin overexpression preserve muscles in aging mice

E Agosti, M De Feudis, E Angelino, R Belli… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
promoting muscle regeneration or preventing skeletal mass loss in different disease models,
including hindlimb ischemia… of muscle atrophy and limiting skeletal muscle regeneration

Regulation of Skeletal Muscle Lipid Metabolism by Ghrelin

EM Hoecht - 2023 - atrium.lib.uoguelph.ca
Unacylated ghrelin (UnAG) has an emerging role in the … Insulin signalling promotes
glucose uptake into skeletal muscleFollowing hind-limb skeletal muscle collection for GSV …

Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury

A Rossetti, G Togliatto, AP Rolo, JS Teodoro… - Cell death …, 2017 - nature.com
Unacylated ghrelin promotes skeletal muscle regeneration following hindlimb ischemia
via SOD-2-mediated miR-221/222 expression. J Am Heart Assoc 2013; 2: e000376. …