mRNA decay: an adaptation tool for the environmental fungal pathogen Cryptococcus neoformans
ALM Bloom, J Leipheimer… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
… specific degradation of subsets of functionally related mRNAs in … major mRNA deadenylase,
CCR4, impairs host temperature … permit mRNA decay to be uncoupled from mRNA synthesis …
CCR4, impairs host temperature … permit mRNA decay to be uncoupled from mRNA synthesis …
[HTML][HTML] Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
ALM Bloom, RM Jin, J Leipheimer, JE Bard… - Nature …, 2019 - nature.com
… , such as Cryptococcus neoformans, is their ability to adapt to … transcript degradation and
mRNA decay in host-temperature … its transcriptome, further impairing its stress responsiveness. …
mRNA decay in host-temperature … its transcriptome, further impairing its stress responsiveness. …
Stress Responsive Translation Regulation in the Human Pathogen Cryptococcus neoformans
CM Knowles - 2023 - search.proquest.com
… ) mRNA decay during oxidative stress from H2O2, but is completely dispensable for adaptation
to host temperature stress of 37C… of mRNA synthesis and mRNA decay, known as mRNA …
to host temperature stress of 37C… of mRNA synthesis and mRNA decay, known as mRNA …
Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans
J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
… by increased concentrations and incubation temperature. Together, these results indicate …
and mRNA decay that drastically affects the ability of the fungal pathogen to adapt to oxidative …
and mRNA decay that drastically affects the ability of the fungal pathogen to adapt to oxidative …
Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction
CM Knowles, D Goich, ALM Bloom, MC Kalem… - Mbio, 2023 - Am Soc Microbiol
… degradation, and mRNA surveillance and decay (26, 32… of Gcn2 to the stress adaptations
we observed in C. … response to temperature is driven mainly by Ccr4-dependent mRNA decay, …
we observed in C. … response to temperature is driven mainly by Ccr4-dependent mRNA decay, …
Transcription Factors and Intracellular Proteins Orchestrate Phenotypic Adaptation in Cryptococcus neoformans for Survival and Human Infections
OS Folorunso, OM Sebolai - 2023 - preprints.org
… Furthermore, cytokinesis in these mutants is impaired and … thermal stress temperature induces
a preponderant mRNA … cytokines, GXM also promotes the uncoupling activity of NF-κB to …
a preponderant mRNA … cytokines, GXM also promotes the uncoupling activity of NF-κB to …
Glucan unmasking identifies regulators of temperature-induced translatome reprogramming in C. neoformans
ALM Bloom, D Goich, CM Knowles, JC Panepinto - Msphere, 2021 - Am Soc Microbiol
… and that, while Ccr4-mediated mRNA decay is not a prerequisite for Mpk1 activation, Ccr4
either directly or indirectly modulates Hog1 activation during host temperature adaptation. …
either directly or indirectly modulates Hog1 activation during host temperature adaptation. …
The novel J-domain protein Mrj1 is required for mitochondrial respiration and virulence in Cryptococcus neoformans
… normal mammalian body temperature (1). Imperative to this … ] was also used to uncouple
proton motive force from oxygen … The explanation that loss of Mrj1 impairs the ETC at …
proton motive force from oxygen … The explanation that loss of Mrj1 impairs the ETC at …
… Gis2 and Znf9 interact with a putative G-quadruplex-forming 3′ untranslated region, altering polysome association and stress tolerance in cryptococcus neoformans
J Leipheimer, ALM Bloom, T Baumstark, JC Panepinto - Msphere, 2018 - Am Soc Microbiol
… adaptation is fundamental to the success of Cryptococcus … to accelerated mRNA decay
during temperature stress in C. … FIG 7 Deletion of GIS2 and ZNF9 affects basal RPL2 decay and …
during temperature stress in C. … FIG 7 Deletion of GIS2 and ZNF9 affects basal RPL2 decay and …
Cryptococcus neoformans requires the TVF1 gene for thermotolerance and virulence
K Ueno, A Nagamori, NO Honkyu, M Kataoka… - Medical …, 2023 - academic.oup.com
… optimal growth temperature is 25–30C, it needs to adapt to … In particular, (1) proteasomal
degradation of aberrant proteins (… cell wall synthesis are associated with the pathogenicity of C. …
degradation of aberrant proteins (… cell wall synthesis are associated with the pathogenicity of C. …