… cytotoxic T cells to tumor cells via BsAb and tumor targeting … , and the ultimate destruction
of the target cell by the ensuing … a universal requirement for redirected T cell cytotoxic activity […

… mechanisms from immune recognition and destruction, such as … Those bispecific ta-scFv
antibodies recognizing a tumor cell … be implemented to the generation of universal STAb-T cells. …

… in the vicinity of the antibody-targeted tumor cell. We generated … be transduced into murine
cytotoxic T cells with comparable … -target effects or organ damage was being caused by SAR T …

… attack and lysis of target tumor cells. Although various bsAb … bsAb, namely, a universal effector
module and a target module, … , alleviating the collateral damage of adjacent healthy tissues…

… that CD28-deficient cytotoxic T-cells were still capable of … D) The copy number of the
targeted antigen on the tumor cell … However, this is not an universal feature as some Ab formats …

… of cytotoxic T lymphocytes and tumor cells due to BsAb binding activates cytotoxic T cells and
promotes the destruction of tumor cells… A relatively universal method of BsAb preparation is …

… damage, preferentially kills regulatory T cells (Treg), induces an acute secretory activating
phenotype in tumor cells … Tnfrsf17 is universally expressed in all normal and malignant PCs at …

… Bispecific antibodies tether tumor cells to T lymphocytes (… also lack a universally expressed
tumor-specific antigen which … and tumor cells (such as granzyme B-mediated damage to the …

… ) T cell therapy combining T cells engrafted with a universal CAR (UniCAR) and an antibody
(Ab)-based component referred to as target … effector cells to avoid permanent destruction of …

… for CD3ɛ present on cytotoxic T cells and one selective for … the ToxiLight non-destructive
cytotoxicity bioassay kit (Lonza) … human T lymphocytes by tumor cells armed with bifunctional …