Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications.
Method PubMed search, selection and review of all independent GWAS in SZ or BD,
published since March 2011, ie studies using non-overlapping samples within each article,
between articles, and with those of the previous review (Li et al., 2012). Results From the 22
GWAS included in this review, the genetic associations surviving standard GWAS …

Neuronal development is a highly regulated mechanism that is central to organismal
function in animals. In humans, disruptions to this process can lead to a range of
neurodevelopmental phenotypes, including Schizophrenia (SCZ). SCZ has a significant
genetic component, whereby an individual with an SCZ affected family member is eight
times more likely to develop the disease than someone with no family history of SCZ. By
examining a combination of genomic, transcriptomic and epigenomic datasets, large-scale …