Response to Letter Regarding Article, “Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation”
…, A Ruhparwar, G Szabó, K Kallenbach… - Circulation, 2016 - Am Heart Assoc
… , I K2P3.1 upregulation, and action potential shortening as substrate in … , K 2P 3.1 K +
channels are important for determining the action potential duration in human atrial myocytes, 1 …
channels are important for determining the action potential duration in human atrial myocytes, 1 …
Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific …
…, G Szabo, A Ruhparwar, K Kallenbach… - European Heart …, 2017 - academic.oup.com
… from patients without HF that show shortened APD [chronic (c)… The present study links
downregulation of repolarizing K 2P … effective in patients with cAF and shortened action potential. …
downregulation of repolarizing K 2P … effective in patients with cAF and shortened action potential. …
Letter by Olschewski et al Regarding Article, “Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation”
A Olschewski, N Chandran, H Olschewski - Circulation, 2016 - Am Heart Assoc
… The current study suggests that the unique 2-pore domain potassium channel TASK-1,
encoded by the human KCNK3 gene, plays an important role as controller of the action potential …
encoded by the human KCNK3 gene, plays an important role as controller of the action potential …
Two-Pore-Domain Potassium (K2P-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
F Wiedmann, N Frey, C Schmidt - Cells, 2021 - mdpi.com
… For example, upregulation of atrial specific K 2P 3.1 (TASK-1) currents in atrial fibrillation (AF)
patients was shown to contribute to atrial action potential duration shortening, a key …
patients was shown to contribute to atrial action potential duration shortening, a key …
pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts
MA Skarsfeldt, TA Jepps, SH Bomholtz… - … -European Journal of …, 2016 - Springer
… outward K + currents throughout the cardiac action potential and … patients with chronic AF,
the upregulation of K 2P 3.1 protein … V 7.1 was accompanied by a significant shortening of APD …
the upregulation of K 2P 3.1 protein … V 7.1 was accompanied by a significant shortening of APD …
Novel ion channel targets in atrial fibrillation
… (I Na ) that underlies the upstroke of the action potential (AP) … negative membrane potential,
and shorter diastolic intervals of … patients with familial AF,[Citation121] and downregulation of …
and shorter diastolic intervals of … patients with familial AF,[Citation121] and downregulation of …
Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system
F Wiedmann, C Schmidt, P Lugenbiel… - Clinical …, 2016 - portlandpress.com
… K 2P currents have been implicated in action potential (AP) … that atrial K 2P 3.1 up-regulation
contributes to AP shortening [30… In this patient population, K 2P 3.1 up-regulation appears to …
contributes to AP shortening [30… In this patient population, K 2P 3.1 up-regulation appears to …
Contribution of two-pore K+ channels to cardiac ventricular action potential revealed using human iPSC-derived cardiomyocytes
S Chai, X Wan, DM Nassal, H Liu… - American Journal …, 2017 - journals.physiology.org
… (42) incriminated enhanced K 2p 3.1 [resulting in shortened APD, … Downregulation of
repolarizing K + currents (with … the downregulation and conceivable role of a K 2p channel (K 2p …
repolarizing K + currents (with … the downregulation and conceivable role of a K 2p channel (K 2p …
Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K+ Channel–Related Acid-Sensitive K+ Channel-1) (K2P3.1) K+ Channels …
…, X Li, S Lang, S Korkmaz-Icöz, K Rapti… - Circulation …, 2019 - Am Heart Assoc
… TASK-1 transcript, protein and ion current levels leading to shortened action potential duration
… Furthermore, this study confirms a role for TASK-1 K + channel upregulation in electrical …
… Furthermore, this study confirms a role for TASK-1 K + channel upregulation in electrical …
Atrial fibrillation: therapeutic potential of atrial K+ channel blockers
U Ravens, KE Odening - Pharmacology & Therapeutics, 2017 - Elsevier
… , ie downregulation of SK channels in chronic atrial fibrillation. … to AF-induced action potential
shortening and that correction of … and closed state with highest potency for K2P3.1 (TASK-…
shortening and that correction of … and closed state with highest potency for K2P3.1 (TASK-…