Anti-mitochondrial antibody titers decrease over time in primary biliary cholangitis patients with ursodeoxycholic acid therapeutic response: a cohort study followed up …

ML Chang, WT Chen, TM Chan, CY Lin… - Frontiers in …, 2022 - frontiersin.org
… to reduce the IgM-AMA but not IgG-AMA levels in peripheral blood mononuclear cells from
Japanese PBC patients after bacterial CpG … in liver cirrhosis caused by autoimmune liver

APASL clinical practice guidance: the diagnosis and management of patients with primary biliary cholangitis

H You, X Ma, C Efe, G Wang, SH Jeong, K Abe… - Hepatology …, 2022 - Springer
… Currently, ursodeoxycholic acid (UDCA) is the treatment of choice for this disease. … M (IgM),
the elevation of NK and NKT cells, as well as noticeable hyperresponsiveness to CpG

Primary Biliary Cholangitis

NV Bergasa - Clinical Cases in Hepatology, 2022 - Springer
… The treatment of PBC is ursodeoxycholic acid (UDCA), which halts the progression of the …
suggest that CpG-B [170] may be a potential endogenous trigger of B cells to produce IgM and …

Immunological abnormalities in patients with primary biliary cholangitis

WT Ma, DK Chen - Clinical science, 2019 - portlandpress.com
… features such as immune system CpG oligodeoxynucleotide … with PBC severity and
ursodeoxycholic acid (UDCA) treatment … B cells may also induce IgM production by these B cells …

Value of baseline IgM level in predicting the treatment response of primary biliary cholangitis

HAN Lin, Q LIANG, XIE Huan, C Ying, M ZHANG… - 临床肝胆病杂志, 2022 - lcgdbzz.org
IgM level and treatment response to ursodeoxycholic acid (UDCA) in patients with primary
biliary cholangitis … the clinical data of 637 PBC patients who were diagnosed and treated with …

EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis

GM Hirschfield, U Beuers, C Corpechot, P Invernizzi… - Journal of …, 2017 - Elsevier
… licensed therapies (ursodeoxycholic acid and obeticholic acid) and off-… on the CPG panel,
and patient representatives were invited … IgM, which may be driven by epigenetic changes [45]. …

[HTML][HTML] Mechanism-based target therapy in primary biliary cholangitis: opportunities before liver cirrhosis?

Y Yang, XS He, M Rojas, PSC Leung… - Frontiers in …, 2023 - frontiersin.org
… Although ursodeoxycholic acid (UDCA) and obeticholic acid (… benefit patients with PBC; it
could normalize the IgM levels … involving the nucleotide cytosine in CpG sites, which typically …

Primary biliary cholangitis: A tale of epigenetically-induced secretory failure?

PM Rodrigues, MJ Perugorria, A Santos-Laso… - Journal of …, 2018 - Elsevier
Ursodeoxycholic acid (UDCA) is the first line therapy (13–15 … However, although partial and
variable methylation on CpG … was also associated with increased serum IgM levels. Later on, …

Primary biliary cholangitis: its pathological characteristics and immunopathological mechanisms

K Tsuneyama, H Baba, Y Morimoto… - The Journal of Medical …, 2017 - jstage.jst.go.jp
… controls after an exposure to CpG, which is a … to ursodeoxycholic acid (UDCA) (54). After
the treatment, serum levels of total IgG, IgM, and IgA as well as those of AMA-IgA and AMA-IgM

Therapeutic trials of biologics in primary biliary cholangitis: an open label study of abatacept and review of the literature

CL Bowlus, GX Yang, CH Liu, CR Johnson… - Journal of …, 2019 - Elsevier
… of treatment remains the bile acid ursodeoxycholic acid (UDCA). … greater amounts of IgM
after stimulation with CpG‐B [18]. … -B after rituximab treatment resulted in significantly lower IgM