… biliary cholangitis, primary sclerosing cholangitis, and … a lot with the introduction of
ursodeoxycholic acid (UDCA), which … AMA positive, with elevated serum IgM and IgG and ALP …

… (AIH), primary biliary cholangitis (PBC), primary sclerosing … Ursodeoxycholic acid (UDCA)
remains one of the therapeutic … plasma and B-cell-induced IgM production [83]. The destruction …

… biliary liver diseases; primary biliary cholangitis (PBC) or … who do not respond to
ursodeoxycholic acid (UDCA) treatment … in PBC patients and hyper IgM production which may be …

… IgM hypergammaglobulinemia and has been implicated in autoimmunity through three main
mechanisms: (i) a decrease … fact that hypomethylation of specific CpGs affects mostly genes …

… T-cells in the autoimmune disease primary biliary cirrhosis and the … AMAs (primarily comprised
of IgM with substantial quantities … Treatment with ursodeoxycholic acid, polymixin B (which …

… rather to ursodeoxycholic acid, a bile salt that induces HCO 3 − … PBC patients, including
development of AMA, increased IgM … a significant increase in CpG-cytosine methylation affecting …

… In patients with primary biliary cholangitis, circulating CXCR5 + and CD4 + T FH cells were
also decreased in number in responders to ursodeoxycholic acid … ligand CpG stimulated IgM …

… is reported to be primarily caused by sex hormones, environmental circumstances, and
epigenetic changes, each of which has a different subtle impact on patients' gender disparities. …

… In addition, ursodeoxycholic acid (UDCA) came into use, … increase in IgM production have
also been reported [24]. … lower AMA titers in the patients with PBC-CREST compared with the …

… of cirrhosis, namely liver surface nodularity and decreased liver size 18 ; … Patient selection
included only female patients who tested AMA positive and were taking ursodeoxycholic acid …