[HTML][HTML] Over-expression of cyclooxygenase-2 in colorectal cancer patients

RR Negi, SV Rana, V Gupta, R Gupta… - … Pacific journal of …, 2019 - ncbi.nlm.nih.gov
… Whereas, no significant change in COX-2 mRNA expression was observed between low
stages and high stages of CRC (p= 0.585). Also, there was no significant correlation between …

Low‐dose aspirin acetylates cyclooxygenase‐1 in human colorectal mucosa: implications for the chemoprevention of colorectal cancer

P Patrignani, A Sacco, C Sostres… - Clinical …, 2017 - Wiley Online Library
The mechanism of action of low‐dose aspirin in the prevention of colorectalcyclooxygenase
(COX)‐1 acetylation at serine‐529 (AceCOX‐1), in blood platelets vs. colorectal mucosa, at

[HTML][HTML] The effectiveness of cyclooxygenase-2 inhibitors and evaluation of angiogenesis in the model of experimental colorectal cancer

H Gungor, N Ilhan, H Eroksuz - Biomedicine & Pharmacotherapy, 2018 - Elsevier
… We think that a statistically insignificant increase in TIMP-2 levels in the DMH-induced CRC
is due to a secondary change towards the increased MMP-2 activity. In the present study, we …

A systematic review of the cyclooxygenase-2 (COX-2) expression in rectal cancer patients treated with preoperative radiotherapy or radiochemotherapy

M Berbecka, A Forma, J Baj… - Journal of Clinical …, 2021 - mdpi.com
… As a result, the expression of COX-2 is elevated in up to 90% of colorectal cancers. It has …
The initial step that aimed to change the treatment guidelines regarding rectal cancer were two …

Combined activity of COX-1 and COX-2 is increased in non-neoplastic colonic mucosa from colorectal neoplasia patients

TSR Jensen, B Mahmood, MB Damm, MB Backe… - BMC …, 2018 - Springer
Cyclooxygenase (COX) activity is increased in endoscopic normal colonic mucosa from
patients with colorectal … by amiloride can therefore be an unrelated variation in salt intake in our …

Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer

BM Kennedy, RE Harris - Inflammopharmacology, 2018 - Springer
… Nevertheless, in the TCGA dataset, expression levels of … for about 50% of the variability in
CYP19A1 among ER-positive … fraction of the variability in CYP19A1 expression was explained …

Understanding the interplay between COX-2 and hTERT in colorectal cancer using a multi-omics analysis

GD Ayiomamitis, G Notas, T Vasilakaki, A Tsavari… - Cancers, 2019 - mdpi.com
… Taken together, the data from our study provide a comprehensive understanding of the
interactions between cyclooxygenases and hTERT in colorectal cancer and may help guide …

Anti-inflammatory effects of enhanced recovery programs on early-stage colorectal cancer surgery

A Venara, E Duchalais, A Dariel, P Aubert… - World Journal of …, 2018 - Springer
… Genes studied were cyclooxygenase 1 and 2 (COX-1 and COX-2), microsomal … the
expression of these genes in the muscularis propria and found no change in COX-2 (p = …

Prostaglandin E2/EP signaling in the tumor microenvironment of colorectal cancer

R Mizuno, K Kawada, Y Sakai - International journal of molecular …, 2019 - mdpi.com
… acids by the enzyme cyclooxygenase-2 (COX-2) and also play pleiotropic roles at inflammatory
sites [15,16]. For example, prostaglandin E2 (PGE2), a major cyclooxygenase product in …

[HTML][HTML] SerpinB3 upregulates the Cyclooxygenase-2/β-Catenin positive loop in colorectal cancer

L Terrin, M Agostini, M Ruvoletto, A Martini… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… , determining a change in the impedance signal. The Cell Index, reflecting the cell number
present in well, was monitored every 10 minutes and calculated as the relative change of …