[HTML][HTML] Mechanisms ensuring endothelial junction integrity beyond VE-cadherin

CN Duong, D Vestweber - Frontiers in Physiology, 2020 - frontiersin.org
… This also highlights a central difference between endothelial junctions in vitro and in vivo. In
… Furthermore, it was found recently that local microvascular leakage promotes movement of …

VE-cadherin endocytosis controls vascular integrity and patterning during development

CM Grimsley-Myers, RH Isaacson, CM Cadwell… - Journal of Cell …, 2020 - rupress.org
… defects in VE-cad DEE/DEE mutants, we performed ex vivo aortic … cadherin-independent
roles for p120 in vascular endothelial … expression levels are the critical determinant controlling …

Vascular endothelial (VE)-cadherin, endothelial adherens junctions, and vascular disease

MG Lampugnani, E Dejana… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
… Consistently, YAP colocalizes with VE-cadherin in vivo in the endothelium of brain and retina
blood vessels, … -cadherin phosphorylation, which result in loss of AJ integrity and impaired …

Interference with ESAM (endothelial cell-selective adhesion molecule) plus vascular endothelial-cadherin causes immediate lethality and lung-specific blood …

CN Duong, AF Nottebaum, S Butz… - … , and Vascular …, 2020 - Am Heart Assoc
… We conclude that ESAM is essential for vascular integrity in … ) with mouse lung microvascular
endothelial cells (MLMVEC) … vivo results (Figure 1C), the mAb BV13 against VE-cadherin

The role of VE-cadherin in blood-brain barrier integrity under central nervous system pathological conditions

W Li, Z Chen, I Chin, Z Chen… - Current …, 2018 - ingentaconnect.com
… , demonstrated that VE-cadherin-mediated brain vascular endothelial cell adhesion … Vascular
endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro. …

TRAIL protects against endothelial dysfunction in vivo and inhibits angiotensin-II-induced oxidative stress in vascular endothelial cells in vitro

PM Cholan, SP Cartland, L Dang, BS Rayner… - Free Radical Biology …, 2018 - Elsevier
… levels may be a determinant of oxidative stress in CAD. … TRAIL in maintaining endothelial
integrity and permeability that … in vitro prevented the AngII-mediated disruption of VE-cadherin

[HTML][HTML] Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

Y Jin, Y Ding, M Richards, M Kaakinen… - Nature Cardiovascular …, 2022 - nature.com
Vascular endothelial (VE)-cadherin in endothelial adherens junctions is an essential component
of the vascular … was seen in vitro; exposure of human umbilical vein endothelial cells (…

Talin-dependent integrin activation regulates VE-cadherin localization and endothelial cell barrier function

FE Pulous, CM Grimsley-Myers, S Kansal… - Circulation …, 2019 - Am Heart Assoc
… junction protein VE (vascular endothelial)-cadherin. Previous … both in vivo and in vitro data
that support a role for talin in VE-… required for AJ stability and integrity of the endothelium. …

Blood endothelium transition and phenotypic plasticity: A key regulator of integrity/permeability in response to ischemia

N Bréchot, A Rutault, I Marangon, S Germain - Seminars in Cell & …, 2023 - Elsevier
… -cadherin antibody was responsible for a major vascular … surface of vascular endothelial
cells and plays a pivotal role for … vivo, microvascular human ECs (HMEC) and human umbilical …

Distinct roles of VEcadherin for development and maintenance of specific lymph vessel beds

R Hägerling, E Hoppe, C Dierkes, M Stehling… - The EMBO …, 2018 - embopress.org
… junctions, which preserve vessel structure and integrity. The … is the transmembrane protein
vascular endothelial (VE)‐cadherin, which … In our model, N‐cadherin upregulation in vivo was …