Vascular endothelial (VE)-cadherin, endothelial adherens junctions, and vascular disease

MG Lampugnani, E Dejana… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
… molecules is crucial for the organization of the nascent vascular … homophilic adhesive
recognition between VE-cadherin … of the intracellular tail of HEG1 (see section on human vascular

Mechanisms ensuring endothelial junction integrity beyond VE-cadherin

CN Duong, D Vestweber - Frontiers in Physiology, 2020 - frontiersin.org
… loss of VE-cadherin and this review will discuss which other adhesive mechanisms contribute
Intercellular junctions enable endothelial cells to form multicellular structures that develop …

Mussel adhesive protein fused with VEcadherin extracellular domain promotes endothelial‐cell tight junctions and in vivo endothelization recovery of vascular stent

D Yang, W Yan, J Qiu, Y Huang, T Li… - Journal of …, 2020 - Wiley Online Library
adhesive protein fused with VE-cadherin extracellular domain (VE-M) specifically triggered
endothelial … stent implants coated with VE-M, we evaluated the clinical applicability of VE-M in …

Molecular mechanism of VE-cadherin in regulating endothelial cell behaviour during angiogenesis

W Nan, Y He, S Wang, Y Zhang - Frontiers in Physiology, 2023 - frontiersin.org
… In addition to its adhesive function, VE-cadherin plays … show that VE-cadherin equilibrium
at intercellular junctions is … Src family kinase (SFK) interacts with the vascular endothelial

VE-cadherin endocytosis controls vascular integrity and patterning during development

CM Grimsley-Myers, RH Isaacson, CM Cadwell… - Journal of Cell …, 2020 - rupress.org
… in adhesive intercellular contacts that … cadherin-p120 complex dictates the plasticity of
endothelial junctions to govern key functions of vascular endothelial cells, including endothelial

Dynamic regulation of vascular permeability by vascular endothelial cadherin-mediated endothelial cell-cell junctions

SS Rho, K Ando, S Fukuhara - Journal of Nippon Medical School, 2017 - jstage.jst.go.jp
… in regulating vascular permeability. VEcadherin mediates intercellular adhesion through …
in a dephosphorylated state, thereby enhancing the adhesive activity of VEcadherin46,47. …

Distinct roles of VEcadherin for development and maintenance of specific lymph vessel beds

R Hägerling, E Hoppe, C Dierkes, M Stehling… - The EMBO …, 2018 - embopress.org
… The central adhesive component of adherence junctions is the transmembrane protein
vascular endothelial (VE)‐cadherin, which mediates its function through extracellular homophilic …

Talin-dependent integrin activation regulates VE-cadherin localization and endothelial cell barrier function

FE Pulous, CM Grimsley-Myers, S Kansal… - Circulation …, 2019 - Am Heart Assoc
… junction protein VE (vascular endothelial)-cadherin. Previous … the affinity of integrins for
extracellular ligands (activation) … junctional stability of other adhesive structures, an observation …

[HTML][HTML] Adaptation of endothelial cells to shear stress under atheroprone conditions by modulating internalization of vascular endothelial cadherin and vinculin

T Zhong, Y Li, X He, Y Liu, Y Dong, H Ma… - Annals of …, 2020 - ncbi.nlm.nih.gov
… Endocytosis of VE-cadherin regulates junctional strength, … VE-cadherin leads to vascular
destabilization, intercellular gap … endothelial cell survival, and an anticoagulant, anti-adhesive

Interference with ESAM (endothelial cell-selective adhesion molecule) plus vascular endothelial-cadherin causes immediate lethality and lung-specific blood …

CN Duong, AF Nottebaum, S Butz… - … , and Vascular …, 2020 - Am Heart Assoc
… PDZ domain containing 1; VE-18) and pAb against the extracellular domain of mouse ESAM
… ESAM could support endothelial junction integrity directly by its adhesive function. Although …