… pestis displays a quite unique set of virulence factors that allow successful infection of fleas
and subversion of immune responses in … a strong lipopolysaccharide response overcame Y. …

… uses a variety of different mechanisms to evade or overcome … of the pathogens’ major
virulence factors, plays a crucial role … pestis instantly begins to produce tetra-acylated LPS, which …

… pestis to be a more powerful TLR-4 stimulant. The change to the stimulatory form of LPS
caused Y.pestis to be … pestis regulates gene expression in response to host colonization. …

… KIM1001ΔT3SE::+yopHEKMAJT is strong evidence that at least one of … pestis must overcome
the antimicrobial host responses … as all other non-T3SS virulence factors, they may prove to …

… strong suppression or evasion of host immune responses to cause disease. Yersinia pestis,
… receptors by microbially associated molecules such as LPS. The second signal is catalyzed …

… A number of virulence factors have been shown to suppress the innate immune response …
As the structure of the lipid A component of LPS is known to induce proinflammatory responses …

… pestis overcomes the innate immunity of its host thanks to many pathogenicity factors, … pestis
or the LPS of E. coli producing Pla negatively impacts Pla activity [40]. Furthermore, gradual …

… transporters Yfe and Feo to overcome the iron deprivation [42… production or the LPS-induced
inflammatory response [52, 53… pestis through arming itself with a variety of virulence factors, …

… ) are central virulence factors for many pathogenic Gram-negative … To counter this, innate
immune responses can also sense … LPS-priming is not required to elicit a strong IL-1β response …

… , inflammatory responses are believed to be suppressed by Y. pestis virulence factors in …
(LPS) appears to antagonize TLR4, minimizing its role in defense against infection (14, 15). …