… In particular, genetic factors have been estimated to play a role in this variability because of
… on the tacrolimus dose required to reach the target exposure in kidney transplant recipients […

… factors potentially impacting tacrolimus metabolism, and represents a simple and inexpensive
tool that could be … , and assist in individualizing and optimizing tacrolimus therapy [7]. …

… , including ethnicity, age, gender, concomitant medication, hepatic and renal dysfunction,
and genetic factors such as CYP3A5, CYP3A4 and ABCB1 SNPs [12, 16, 124]. Among them, …

… along with pharmacogenetics of tacrolimus in pediatric patients undergoing kidney
transplantation to identify factors that explain variability and determine dosage regimens. These …

… 6th-day tacrolimus C 0 /D ratio with multiple factors, including … A dosing equation to calculate
the required tacrolimus dose/… have been made to optimize tacrolimus dosing based on the …

… The authors concluded that optimization of initial Tac dosing using CYP3A5 … the first
dosing algorithm using a combination of genetic information and clinical factors in adult kidney …

… In kidney transplantation, tacrolimus (TAC) is at the cornerstone … , physiologic but also genetic
factors. It was suggested that … fuel the state-of-the-art in regard to TAC therapy optimization …

… was to merge genetic and non-genetic factors of tacrolimus … dosage regimen in Chinese
nephrotic syndrome patients. … with higher tacrolimus concentrations in liver or kidney transplant …

… AMT but without genetic factors having been clearly identified. Symptoms of acute … genetic
polymorphism as a biomarker in the use of tacrolimus might prevent drug toxicity and optimize …

… disturbances, drug–drug interactions, genetic factors and importantly, non-adherence […
clinical benefit, concluding that optimizing the initial Tac dose based on CYP3A5 genotype …