… (BMD) and increased susceptibility to low trauma fractures. It … a large effect size near a novel
locus EN1 (6), whereas another … This study aims to propose novel genetic determinants of …

… genetic variation near EN1 and common variation near SOX6 operates in childhood and has
implications for the lifelong risk of osteoporosis and fracture. … genetic determinants of bone …

… This approach interrogates the whole genome to search for … The growing number of loci for
bone density highlights the … and 3′ regulatory regions of the EN1 gene was also found to be …

… Such other determinants of bone strength like geometry, … EN1 is another important novel
gene involved in murine … polygenic traits such as bone density and can drastically improve the …

… GWAS approach interrogates the whole genome to search for … genetic determinants of bone
density in adult may identify … role of EN1 in bone metabolism, we generated En1 knockout …

… It has been demonstrated that EN1 is a determinant of bone density and fracture, which is …
calvarial intramembranous bone formation and limb development [20, 22, 23]. EN1 encodes a …

… reported EN1 locus 14 . … sequenced the whole genomes of 2,636 Icelanders using Illumina
technology to a mean depth of at least × 10 (median × 20). SNPs and indels were identified …

… We conducted whole exome sequencing on DNA of three cases, performed candidate …
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature. …

… low bone mineral density and an increased risk of fracture, … For example, the GEnetic Factors
for OSteoporosis (GEFOS) … , has identified dozens of new susceptibility loci (such as EN1) …

… of the biology underlying low bone density that may point to … (ES) and whole genome
sequencing (WGS), have emerged … En1 −/− mice recapitulated the low bone mass phenotype …