Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer
… the etiology of pancreatic cancer and for the identification of susceptibility … Genomes Project
and EVS, we compared our findings in the 87 selected genes to whole exome sequencing …
and EVS, we compared our findings in the 87 selected genes to whole exome sequencing …
Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches
… genome including pancreatic cancer. In this review we discuss the characteristics of genomic
instability in pancreatic cancer … A recent whole exome study also elucidated sensitivity of …
instability in pancreatic cancer … A recent whole exome study also elucidated sensitivity of …
[HTML][HTML] Identification of key genes mutations associated with the radiosensitivity by whole exome sequencing in pancreatic cancer
B Hu, X Ma, R Huang, Z Wu, J Lu, Y Guo, J Tang… - Frontiers in …, 2021 - frontiersin.org
… To identify the critical mutations of affecting radiotherapy benefit in PC, whole exome
sequencing was utilized in six pancreatic ductal adenocarcinoma (PDAC) patients (three with a …
sequencing was utilized in six pancreatic ductal adenocarcinoma (PDAC) patients (three with a …
[HTML][HTML] Mutational burden of resectable pancreatic cancer, as determined by whole transcriptome and whole exome sequencing, predicts a poor prognosis
E Grassi, S Durante, A Astolfi… - International …, 2018 - spandidos-publications.com
… Despite the genomic characterization of pancreatic cancer (PC), marked advances in the
development of prognosis classification and novel therapeutic strategies have yet to come. The …
development of prognosis classification and novel therapeutic strategies have yet to come. The …
[HTML][HTML] Genomic characterization of malignant progression in neoplastic pancreatic cysts
… lesions and invasive pancreatic cancers, we performed whole exome sequencing of 39 …
and associated invasive cancers, suggesting that global genomic instability may be important as …
and associated invasive cancers, suggesting that global genomic instability may be important as …
Candidate DNA repair susceptibility genes identified by exome sequencing in high-risk pancreatic cancer
AL Smith, N Alirezaie, A Connor, M Chan-Seng-Yue… - Cancer letters, 2016 - Elsevier
… repair candidate gene approach to interrogate whole exome sequencing (WES) data for novel
… In summary, we have undertaken the first detailed characterization of germline variants in …
… In summary, we have undertaken the first detailed characterization of germline variants in …
Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine
AJ Aguirre, JA Nowak, ND Camarda, RA Moffitt… - Cancer discovery, 2018 - AACR
… ductal adenocarcinoma (PDAC), but molecular characterization is … whole-exome sequencing
and RNA sequencing for patients with advanced PDAC. Therapeutically relevant genomic …
and RNA sequencing for patients with advanced PDAC. Therapeutically relevant genomic …
Next-generation sequencing in pancreatic cancer
GQ Shen, EM Aleassa, RM Walsh, G Morris-Stiff - Pancreas, 2019 - journals.lww.com
… This scale of genomic instability suggested defects in DNA maintenance, which … analysis
has revealed that the GNAS mutation is also frequent in IPMN. Whole-exome sequencing …
has revealed that the GNAS mutation is also frequent in IPMN. Whole-exome sequencing …
From somatic mutation to early detection: insights from molecular characterization of pancreatic cancer precursor lesions
CG Fischer, LD Wood - The Journal of pathology, 2018 - Wiley Online Library
… More recently, targeted and whole exome sequencing studies have demonstrated that only
15% of high-grade PanINs had TP53 mutations, and none harbored mutations in SMAD4 11, …
15% of high-grade PanINs had TP53 mutations, and none harbored mutations in SMAD4 11, …
[HTML][HTML] Using Exome Sequencing to Improve Prediction of FOLFIRINOX First Efficacy for Pancreatic Adenocarcinoma
J Lecuelle, A Aarnink, Z Tharin, C Truntzer… - Cancers, 2021 - mdpi.com
… ; Figure S2: Mutational signature analysis of whole exome sequencing data from the whole
population of pancreatic tumors; Figure S3: Analysis of homologous repair aberrations, SNV …
population of pancreatic tumors; Figure S3: Analysis of homologous repair aberrations, SNV …