Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer

NJ Roberts, AL Norris, GM Petersen, ML Bondy… - Cancer discovery, 2016 - AACR
… the etiology of pancreatic cancer and for the identification of susceptibility … Genomes Project
and EVS, we compared our findings in the 87 selected genes to whole exome sequencing

Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches

IH Sahin, MA Lowery, ZK Stadler… - Expert review of …, 2016 - Taylor & Francis
genome including pancreatic cancer. In this review we discuss the characteristics of genomic
instability in pancreatic cancer … A recent whole exome study also elucidated sensitivity of …

[HTML][HTML] Identification of key genes mutations associated with the radiosensitivity by whole exome sequencing in pancreatic cancer

B Hu, X Ma, R Huang, Z Wu, J Lu, Y Guo, J Tang… - Frontiers in …, 2021 - frontiersin.org
… To identify the critical mutations of affecting radiotherapy benefit in PC, whole exome
sequencing was utilized in six pancreatic ductal adenocarcinoma (PDAC) patients (three with a …

[HTML][HTML] Mutational burden of resectable pancreatic cancer, as determined by whole transcriptome and whole exome sequencing, predicts a poor prognosis

E Grassi, S Durante, A Astolfi… - International …, 2018 - spandidos-publications.com
… Despite the genomic characterization of pancreatic cancer (PC), marked advances in the
development of prognosis classification and novel therapeutic strategies have yet to come. The …

[HTML][HTML] Genomic characterization of malignant progression in neoplastic pancreatic cysts

M Noë, N Niknafs, CG Fischer, WM Hackeng… - Nature …, 2020 - nature.com
… lesions and invasive pancreatic cancers, we performed whole exome sequencing of 39 …
and associated invasive cancers, suggesting that global genomic instability may be important as …

Candidate DNA repair susceptibility genes identified by exome sequencing in high-risk pancreatic cancer

AL Smith, N Alirezaie, A Connor, M Chan-Seng-Yue… - Cancer letters, 2016 - Elsevier
… repair candidate gene approach to interrogate whole exome sequencing (WES) data for novel
… In summary, we have undertaken the first detailed characterization of germline variants in …

Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine

AJ Aguirre, JA Nowak, ND Camarda, RA Moffitt… - Cancer discovery, 2018 - AACR
… ductal adenocarcinoma (PDAC), but molecular characterization is … whole-exome sequencing
and RNA sequencing for patients with advanced PDAC. Therapeutically relevant genomic

Next-generation sequencing in pancreatic cancer

GQ Shen, EM Aleassa, RM Walsh, G Morris-Stiff - Pancreas, 2019 - journals.lww.com
… This scale of genomic instability suggested defects in DNA maintenance, which … analysis
has revealed that the GNAS mutation is also frequent in IPMN. Whole-exome sequencing

From somatic mutation to early detection: insights from molecular characterization of pancreatic cancer precursor lesions

CG Fischer, LD Wood - The Journal of pathology, 2018 - Wiley Online Library
… More recently, targeted and whole exome sequencing studies have demonstrated that only
15% of high-grade PanINs had TP53 mutations, and none harbored mutations in SMAD4 11, …

[HTML][HTML] Using Exome Sequencing to Improve Prediction of FOLFIRINOX First Efficacy for Pancreatic Adenocarcinoma

J Lecuelle, A Aarnink, Z Tharin, C Truntzer… - Cancers, 2021 - mdpi.com
… ; Figure S2: Mutational signature analysis of whole exome sequencing data from the whole
population of pancreatic tumors; Figure S3: Analysis of homologous repair aberrations, SNV …