YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
YB-1 promotes the progression of multiple tumor types and serves as a potential tumor
biomarker and therapeutic target. … of YB-1 in cancers, and further discusses targeted strategies. …

[HTML][HTML] Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

PK Maurya, A Mishra, BS Yadav, S Singh… - Journal of …, 2017 - ncbi.nlm.nih.gov
… It is a vital oncoprotein that regulates cancer cell progression … of YB-1 as a potential biomarker
as well as therapeutic target … cancer cells make YB-1 a powerful prognostic marker. Many …

Y box binding protein 1 (YB-1) oncoprotein at the hub of DNA proliferation, damage and cancer progression

F Sangermano, A Delicato, V Calabrò - Biochimie, 2020 - Elsevier
… nuclear YB-1 could be a prognostic marker for multi-drug resistance in osteosarcoma however,
the molecular mechanism driving nuclear translocation of YB-1Therapeutic targeting of …

A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance

A Alkrekshi, W Wang, PS Rana, V Markovic… - Cellular signalling, 2021 - Elsevier
… to the multiple physiological functions of YB-1. We will also review the role of YB-1 in cancer
development, progression, metastasis, and drug resistance in various malignancies, with …

YB-1 protein in breast cancer (scientific and personal meetings with Professor Ovchinnikov)

GP Guens - Biochemistry (Moscow), 2022 - Springer
… that YB-1 is at the crossroads of signaling pathways involved in all cancer hallmarks make
this oncoprotein an extremely attractive therapeutic target. Upregulated YB-1 expression …

Potential therapeutic strategies for targeting Y-Box-binding protein 1 in cancers

JW Yang, C Sun, QY Jin, XH Qiao… - … Cancer Drug Targets, 2021 - ingentaconnect.com
… been developed to target YB-1 for cancer therapy. In this review, we … YB-1 in detail, highlight
the role of YB-1 in tumors and summarize the current therapeutic methods for targeting YB-1

[HTML][HTML] Serum YB-1 (Y-box binding protein 1) as a biomarker of bone disease progression in patients with breast cancer and bone metastases

AR Ferreira, M Bettencourt, I Alho, AL Costa… - Journal of Bone …, 2017 - Elsevier
… In BC, YB-1 is a prognostic marker of disease aggressiveness … treatment with BPs (shortly
after BM diagnosis). In our cohort we observed that the secreted form of the oncoprotein YB-1

Why be one protein when you can affect many? The multiple roles of YB-1 in lung cancer and mesothelioma

TG Johnson, K Schelch, S Mehta, A Burgess… - Frontiers in cell and …, 2019 - frontiersin.org
… multifunctional oncoprotein Y-box binding protein-1 (YB-1) … Here, we review the regulation
of YB-1 at the transcriptional, … its potential use as a biomarker and therapeutic target. …

[HTML][HTML] Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer

MC Huber, N Falkenberg, SM Hauck, M Priller… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… The scope of the present study was to identify novel interacting partners of uPAR that may
be potential therapeutic targets or of clinical relevance. Therefore, precipitates derived from …

[HTML][HTML] Positive expression of Y-box binding protein 1 and prognosis in non-small cell lung cancer: a meta-analysis

L Jiang, GL Yuan, QL Liang, HJ Zhang, J Huang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… for the development of therapeutic targets for this receptor. … In conclusion, this meta-analysis
showed that YB-1 … that YB-1 may be a poor prognostic factor and therapeutic target in …