Clinical implications of Pseudomonas aeruginosa location in the lungs of patients with cystic fibrosis

JE Moore, P Mastoridis - Journal of Clinical Pharmacy and …, 2017 - Wiley Online Library
… A recent review of inhaled antibiotic therapy, and the common devices used in CF,
concluded that to maximize the utility of aerosolized antibiotics, we must first gain a better …

Off‐label use of intravenous antimicrobials for inhalation in patients with cystic fibrosis

CJ McKinzie, L Chen, K Ehlert, AG Grisso… - Pediatric …, 2019 - Wiley Online Library
… .7, 8 Similar to inhaled tobramycin, the CFF Guidelines for … or against the chronic use of other
inhaled antibiotics (ie, carbenicillin, … use of other nebulized antibiotics including ceftazidime, …

Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis

S Smith, NJ Rowbotham - Cochrane Database of Systematic …, 2022 - cochranelibrary.com
Inhaled antibiotics compared to placebo We found that inhaled antibiotics may improve lung
… Compared to placebo, inhaled antibiotics may also reduce the frequency of exacerbations (…

Inhalable antimicrobials for treatment of bacterial biofilm-associated sinusitis in cystic fibrosis patients: challenges and drug delivery approaches

SN Kłodzińska, PA Priemel, T Rades… - International Journal of …, 2016 - mdpi.com
… , many European CF centers and the American Cystic Fibrosis Foundation (CFF) recommend
aggressive antimicrobial treatment with inhaled tobramycin as soon as P. aeruginosa is …

Nebulized gentamicin in combination with systemic antibiotics for eradicating early Pseudomonas aeruginosa infection in children with cystic fibrosis

B Van Stormbroek, M Zampoli… - Pediatric …, 2019 - Wiley Online Library
Cystic fibrosis (CF) is one of the more common recessive genetic disorders affecting all … in
children with CF, most consisting of inhaled antibiotics with or without the addition of systemic …

Evaluation of aerosol therapy during the escalation of care in a model of adult cystic fibrosis

E Fernandez Fernandez, M Joyce, A O'Sullivan… - Antibiotics, 2021 - mdpi.com
… on aerosol therapy during the escalation of care using a bench model of adult CF. Droplet
size analysis of selected antibiotics was completed in tandem with the delivered aerosol dose (…

The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis

IF Laska, ML Crichton, A Shoemark… - The lancet respiratory …, 2019 - thelancet.com
… Although use of inhaled antibiotics is the standard of care in cystic fibrosis, there is … support
use of inhaled antibiotics in patients with bronchiectasis not due to cystic fibrosis. We aimed …

Adjunctive nebulized antibiotics: what is their place in ICU infections?

MS Niederman - Frontiers in Medicine, 2019 - frontiersin.org
… Conceptually, inhaled antibiotics can be applied when traditional therapy is failing, or they …
aerosolized antibiotics for ICU patients, the methods of delivery, and recent data with inhaled

Inhaled antibiotic use is associated with Scedosporium/Lomentospora species isolation in cystic fibrosis

G Hong, N Lechtzin, D Hadjiliadis… - Pediatric …, 2019 - Wiley Online Library
… The association between inhaled antibiotics and Scedosporium informs us that chronic
inhaled antibiotics may be playing a role in Scedosporium isolation. Further investigation to …

Inhaled antibiotics for treatment of adults with non-cystic fibrosis bronchiectasis: A systematic review and meta-analysis

S Tejada, L Campogiani, C Solé-Lleonart… - European Journal of …, 2021 - Elsevier
… The US bronchiectasis research registry reports the use of suppressive inhaled antibiotics
(IA) in 10% of patients (7). Cystic fibrosis guidelines (8) recommend IA in all cystic fibrosis