[HTML][HTML] From ancient pathways to aging cells—connecting metabolism and cellular senescence
CD Wiley, J Campisi - Cell metabolism, 2016 - cell.com
… suppression responses, such as cellular senescence. These new findings demonstrate how
cancer, senescence, and aging can be linked in part through common metabolic processes. …
cancer, senescence, and aging can be linked in part through common metabolic processes. …
ROS, cell senescence, and novel molecular mechanisms in aging and age‐related diseases
P Davalli, T Mitic, A Caporali… - … medicine and cellular …, 2016 - Wiley Online Library
… ability of inducing cell senescence through novel mechanisms that underpin aging processes.
… models have advanced our understanding of pathways that lead to age-related features, …
… models have advanced our understanding of pathways that lead to age-related features, …
Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction
Y Zhu, X Liu, X Ding, F Wang, X Geng - Biogerontology, 2019 - Springer
… aging through multiple pathways. In this review, we summarized the main mechanisms of
cellular senescence, mitochondrial malfunction and aging … involved in the aging process may …
cellular senescence, mitochondrial malfunction and aging … involved in the aging process may …
[HTML][HTML] CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases
M Zhao, L Chen, H Qu - Cell death & disease, 2016 - nature.com
… cell senescence genes in a pathway context, we extracted PPIs between 504 cell senescence
… This provides a broader biological picture associated with cell aging. To this end, a non-…
… This provides a broader biological picture associated with cell aging. To this end, a non-…
[HTML][HTML] Mitochondrial dysfunction in cell senescence and aging
… we summarize pathways that cause mitochondrial dysfunction in senescence and aging and
… these consequences contribute to senescence and aging. We also highlight the potential of …
… these consequences contribute to senescence and aging. We also highlight the potential of …
Aging, cell senescence, and chronic disease: emerging therapeutic strategies
T Tchkonia, JL Kirkland - Jama, 2018 - jamanetwork.com
… accelerate immune removal of senescent cells, agents that recognize senescent cells and
deliver a toxin, and drugs that target the metabolic pathways that senescent cells depend on. …
deliver a toxin, and drugs that target the metabolic pathways that senescent cells depend on. …
[HTML][HTML] Cellular senescence in the aging and diseased kidney
FA Valentijn, LL Falke, TQ Nguyen… - Journal of cell …, 2018 - Springer
… In this review, we discuss (i) current understanding of the mechanisms and associated
pathways of senescence, (ii) evidence of senescence occurrence and causality with organ injury, …
pathways of senescence, (ii) evidence of senescence occurrence and causality with organ injury, …
[HTML][HTML] Factors and pathways modulating endothelial cell senescence in vascular aging
… Numerous molecules and pathways, including sirtuins, Klotho, RAAS, … EC senescence.
This review summarizes the molecular players and signaling pathways driving EC senescence …
This review summarizes the molecular players and signaling pathways driving EC senescence …
Cellular senescence and tumor promotion: Is aging the key?
N Loaiza, M Demaria - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2016 - Elsevier
… In the present review, we present a summary of the current knowledge regarding the
causes, effector pathways and cellular features of senescence. We also discuss how the …
causes, effector pathways and cellular features of senescence. We also discuss how the …
[HTML][HTML] Therapeutic interventions for aging: the case of cellular senescence
A Soto-Gamez, M Demaria - Drug Discovery Today, 2017 - Elsevier
… cell and non-cell autonomous effects. Here, we summarize the mechanisms by which cellular
senescence can promote aging, … pro-survival pathways active in senescent cells leading to …
senescence can promote aging, … pro-survival pathways active in senescent cells leading to …
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