… PNPLA3 is closely involved with lipid metabolism and is a risk factor for non-alcoholic fatty
liver disease (NAFLD) and HCC, suggesting that it plays an integral role in maintaining liver …

… NAFLD has a bidirectional association with components of … NAFLD are cardiovascular
disease and extrahepatic malignancy, advanced liver fibrosis is a key prognostic marker for liver-…

… liver disease because a number of disease modifiers exacerbate, slow, or prevent alcoholic
liver disease … therapies for treating patients with alcoholic liver disease. Cessation of drinking …

… non-alcoholic fatty liver disease. As there is no specific biomarker for the diagnosis of
ALD, diagnosis requires excluding other liver diseases in a patient with heavy alcohol use. …

Alcoholic liver disease (ALD) includes a broad spectrum of disorders, such as simple
steatosis, cirrhosis, acute alcoholic … liver diseases, including nonalcoholic liver disease (NAFLD) …

… Alcohol use disorders (AUD) are the most frequent cause of liver cirrhosis in Europe, and
alcoholic liver disease (ALD) the most important cause of death due to alcohol in adults. …

… Alcoholic liver diseases comprise a spectrum of clinical disorders and changes in liver tissue
… These range from steatosis to more severe signs and symptoms of liver disease associated …

… only occasionally in the setting of chronic liver disease that has not yet progressed to cirrhosis…
HCC occurs in patients with NAFLD compared to other causes of chronic liver disease [12]. …

… The increase in Non-alcoholic Fatty Liver Disease (NAFLD) and the imminent … liver disease.
NAFLD-cirrhosis or NAFLD-Hepatocellular Carcinoma (HCC) are now the second cause of …

… cause such as alcohol or drugs. It encompasses a spectrum of disease from non-alcoholic
fatty liver (NAFL) through to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. …