… lifestyle interventions targeting general brain health to jointly combat the disease. In this … In
panel 1, we describe two cases, which show the range of Alzheimer's disease in terms of age …

… the human brain transcriptome in Alzheimer's disease (AD), based on meta-analysis of
differential gene expression in 2,114 postmortem samples. We discover 30 brain … with 251 brain …

… Recently, we used BigData approach to propose an analysis of brain trajectory across the …
the human brain in AD. To this end, we propose to build an extrapolated model of AD for brain …

… changes in human brain methylation and that aberrant alteration of brain methylation … human
brain-derived starting material, ie, fresh frozen versus paraformaldehyde-fixed human brain…

… , we identify a core brain proteome that exhibits only … brains and our aged cohort. Our
findings suggest considerable value in examining specifically the brain proteome of aged human …

… Lifestyle factors do not directly affect Alzheimer's disease pathology, but can still contribute
to a positive outcome in individuals with Alzheimer's disease. … Brain. 2015; 138: 3673-3684 …

… in the brain, we took an indirect approach to sort DEGs and gDTUs according to individual
cell types. To that, we used scRNAseq data obtained from the adult human brain to identify …

There is a need for new therapeutic targets with which to prevent Alzheimer’s disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …

Introduction One major factor that influences the heterogeneity of Alzheimer's disease (AD)
is age: younger AD patients more frequently exhibit atypical forms of AD. We propose that …

… to produce physiologically relevant human tissues to study AD using human-induced neural
… brain model. We report a herpes-induced tissue model of AD that mimics human disease …