Alzheimer's disease
… lifestyle interventions targeting general brain health to jointly combat the disease. In this … In
panel 1, we describe two cases, which show the range of Alzheimer's disease in terms of age …
panel 1, we describe two cases, which show the range of Alzheimer's disease in terms of age …
[HTML][HTML] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
… the human brain transcriptome in Alzheimer's disease (AD), based on meta-analysis of
differential gene expression in 2,114 postmortem samples. We discover 30 brain … with 251 brain …
differential gene expression in 2,114 postmortem samples. We discover 30 brain … with 251 brain …
Lifespan changes of the human brain in Alzheimer's disease
… Recently, we used BigData approach to propose an analysis of brain trajectory across the …
the human brain in AD. To this end, we propose to build an extrapolated model of AD for brain …
the human brain in AD. To this end, we propose to build an extrapolated model of AD for brain …
Epigenomics of Alzheimer's disease
… changes in human brain methylation and that aberrant alteration of brain methylation … human
brain-derived starting material, ie, fresh frozen versus paraformaldehyde-fixed human brain…
brain-derived starting material, ie, fresh frozen versus paraformaldehyde-fixed human brain…
Proteomic atlas of the human brain in Alzheimer's disease
J McKetney, RM Runde, AS Hebert… - Journal of proteome …, 2019 - ACS Publications
… , we identify a core brain proteome that exhibits only … brains and our aged cohort. Our
findings suggest considerable value in examining specifically the brain proteome of aged human …
findings suggest considerable value in examining specifically the brain proteome of aged human …
Alzheimer's disease
… Lifestyle factors do not directly affect Alzheimer's disease pathology, but can still contribute
to a positive outcome in individuals with Alzheimer's disease. … Brain. 2015; 138: 3673-3684 …
to a positive outcome in individuals with Alzheimer's disease. … Brain. 2015; 138: 3673-3684 …
Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains
D Marques-Coelho, LCC Iohan… - … Mechanisms of Disease, 2021 - nature.com
… in the brain, we took an indirect approach to sort DEGs and gDTUs according to individual
cell types. To that, we used scRNAseq data obtained from the adult human brain to identify …
cell types. To that, we used scRNAseq data obtained from the adult human brain to identify …
A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease
S Mostafavi, C Gaiteri, SE Sullivan, CC White… - Nature …, 2018 - nature.com
There is a need for new therapeutic targets with which to prevent Alzheimer’s disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …
a major contributor to aging-related cognitive decline. Here we report the construction and …
Alzheimer's disease: The influence of age on clinical heterogeneity through the human brain connectome
…, Alzheimer's Disease Neuroimaging Initiative - Alzheimer's & Dementia …, 2017 - Elsevier
Introduction One major factor that influences the heterogeneity of Alzheimer's disease (AD)
is age: younger AD patients more frequently exhibit atypical forms of AD. We propose that …
is age: younger AD patients more frequently exhibit atypical forms of AD. We propose that …
A 3D human brain–like tissue model of herpes-induced Alzheimer's disease
DM Cairns, N Rouleau, RN Parker, KG Walsh… - Science …, 2020 - science.org
… to produce physiologically relevant human tissues to study AD using human-induced neural
… brain model. We report a herpes-induced tissue model of AD that mimics human disease …
… brain model. We report a herpes-induced tissue model of AD that mimics human disease …
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