Antigen receptor structure and signaling
F Han, Y Chen, Y Zhu, Z Huang - Advances in Immunology, 2023 - Elsevier
… structural resolution, based on antigen recognition receptors … , elicit effective antigen-specific
neutralizing antibodies and … In conclusion, the study of antigen receptors structure and …
neutralizing antibodies and … In conclusion, the study of antigen receptors structure and …
[HTML][HTML] Comparative analysis of the CDR loops of antigen receptors
… If we consider structures with a difference of <1Åin backbone RMSD as similar (… antibodies),
this analysis illustrates that the majority of the sequence-identical structures are structurally …
this analysis illustrates that the majority of the sequence-identical structures are structurally …
[HTML][HTML] Structure analysis of the receptor binding of 2019-nCoV
Y Chen, Y Guo, Y Pan, ZJ Zhao - Biochemical and biophysical research …, 2020 - Elsevier
… We performed a structural analysis of the receptor binding domain (RBD) of spike glycoprotein
responsible for entry of coronaviruses into host cells. The RBDs from the two viruses …
responsible for entry of coronaviruses into host cells. The RBDs from the two viruses …
Impact of scFv structure in chimeric antigen receptor on receptor expression efficiency and antigen recognition properties
K Fujiwara, M Masutani, M Tachibana… - … and biophysical research …, 2020 - Elsevier
… expressing chimeric antigen receptor (CAR… antigen specificity and reactivity of CAR-T cells
are defined by CAR expression level and affinity, information on optimizing the scFv structure …
are defined by CAR expression level and affinity, information on optimizing the scFv structure …
ANARCI: antigen receptor numbering and receptor classification
… We have developed ANARCI, a program for annotating antigen receptor variable domain
amino-acid sequences with five commonly used numbering schemes. The program can be run …
amino-acid sequences with five commonly used numbering schemes. The program can be run …
[HTML][HTML] Chimeric antigen receptor T cell structure, its manufacturing, and related toxicities; A comprehensive review
… the complete chimeric antigen receptor through a hydrophobic alpha-helix structure. The
CD28 transmembrane domain is known to result in a highly expressed, stable receptor [49]. …
CD28 transmembrane domain is known to result in a highly expressed, stable receptor [49]. …
CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody–Antigen Interface
Y Liu, J Pan, S Jenni, DD Raymond… - Journal of molecular …, 2017 - Elsevier
… Structure-based vaccine design depends on extensive structural analyses of antigen–antibody
complexes.Single-particle electron cryomicroscopy (cryoEM) can circumvent some of the …
complexes.Single-particle electron cryomicroscopy (cryoEM) can circumvent some of the …
[HTML][HTML] Sequence and structural analyses reveal distinct and highly diverse human CD8+ TCR repertoires to immunodominant viral antigens
… A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections. However…
to defined viral antigens is limited. We performed a comprehensive analysis of CD8 + TCR …
to defined viral antigens is limited. We performed a comprehensive analysis of CD8 + TCR …
[HTML][HTML] Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
MS Hwang, MS Miller, P Thirawatananond… - Nature …, 2021 - nature.com
… To deepen the understanding of 2Q1 recognition, we aligned and performed subsequent
structural analysis of the HLA-B allomorphs, focusing on polymorphic residues that could affect …
structural analysis of the HLA-B allomorphs, focusing on polymorphic residues that could affect …
Membrane organization and physical regulation of lymphocyte antigen receptors: A biophysicist's perspective
L Limozin, PH Puech - The Journal of Membrane Biology, 2019 - Springer
… At the molecular level, antigenic receptors have the capability of recognising a huge
diversity of molecules due to combinatorial variations in recognising motifs. Understanding how …
diversity of molecules due to combinatorial variations in recognising motifs. Understanding how …
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- chimeric antigen receptor
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