Efficacy of repurposed antiviral drugs: lessons from COVID-19

MA Martinez - Drug Discovery Today, 2022 - Elsevier
… Several repurposed drugs have been assessed clinically, … New antiviral drugs targeting
different SARS-CoV-2 enzymes … will see the impact of these newly developed drugs on COVID-19…

[HTML][HTML] Antiretroviral drugs impact autophagy with toxic outcomes

L Cheney, JM Barbaro, JW Berman - Cells, 2021 - mdpi.com
… highlights the gaps in our knowledge of the impacts of antiretroviral drugs on autophagy. …
impact of antiretroviral drugs on autophagy as they relate to clinical side effects and toxicities. …

[HTML][HTML] Candidate antiviral drugs for COVID-19 and their environmental implications: a comprehensive analysis

P Biswas, MM Hasan, D Dey… - … Science and Pollution …, 2021 - Springer
… summarized the epidemiological and clinical data from several clinical trials conducted since
… The restrictions on travel and businesses significantly impacted the economic condition, …

The importance of resistance to direct antiviral drugs in HCV infection in clinical practice

C Sarrazin - Journal of hepatology, 2016 - Elsevier
… time, susceptibility to additional antiviral agents is reduced or duration of treatment is
suboptimal. In this review geno- and phenotypic resistance testing as well as clinical data on the …

A review: Mechanism of action of antiviral drugs

S Kausar, F Said Khan… - International journal …, 2021 - journals.sagepub.com
… currently used antiviral drugs, mechanism of action and antiviral agents … potential have
been developed for clinical use for the treatment of … Antagonistic impacts of antiviral drugs

[HTML][HTML] Direct acting anti-hepatitis C virus drugs: clinical pharmacology and future direction

A Geddawy, YF Ibrahim, NM Elbahie… - Journal of translational …, 2017 - degruyter.com
… The impact of drug-drug interaction depends upon many factors including the patient’s age,
sex, genomics… Drug-drug interactions during antiviral therapy for chronic hepatitis C. Nat Rev …

Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment

Y Wang, L Chen - European Journal of Pharmacology, 2020 - Elsevier
… Currently, many antiviral drugs have been tested in COVID-19 clinical trials and their
clinical … How potent the drugs are in vitro and how the drugs work might also impact on their …

The impact of age on antiretroviral drug pharmacokinetics in the treatment of adults living with HIV

A Calcagno, M Trunfio, A D'Avolio… - … Opinion on Drug …, 2021 - Taylor & Francis
… of antiretroviral medications (ARVs), fewer drug regimens have … combination antiretroviral
therapies: conversely antiviral … in several antiretroviral drugs but the clinical relevance of …

The impact of direct‐acting antivirals on hepatitis C viraemia among people who inject drugs in England; real‐world data 2011–2018

M Bardsley, E Heinsbroek, R Harris… - Journal of viral …, 2021 - Wiley Online Library
… As countries push towards elimination goals, ‘real-world’ data on the impact of scaling up
HCV … We aim to assess the early impact of DAA scale-up in England by examining changes in …

Real‐world impact of direct acting antiviral therapy on health‐related quality of life in HIV/Hepatitis C co‐infected individuals

S Saeed, EEM Moodie, E Strumpf, J Gill… - Journal of viral …, 2018 - Wiley Online Library
… Secondly, similar to the clinical trials we observed an immediate impact of HCV treatment
response, from baseline to response, albeit not as strong. However, assessing changes in …