Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer
… CpG sites. We showed that the methyl-CpG-binding protein MBD2 preferentially binds to the
‘… Methylated CpG density was calculated as the number of CpG sites with methylation above …
‘… Methylated CpG density was calculated as the number of CpG sites with methylation above …
CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands
LN van de Lagemaat, M Flenley, MD Lynch… - Epigenetics & …, 2018 - Springer
… genomic features found that CpG density, H3K4me3 intensity … approximately 48% of CFP1
binding in open chromatin. This … : (1) binding of its ZF-CxxC domain to CpG dinucleotides; (2) …
binding in open chromatin. This … : (1) binding of its ZF-CxxC domain to CpG dinucleotides; (2) …
Methyl‐CpG‐binding protein (MBD) family: epigenomic read‐outs functions and roles in tumorigenesis and psychiatric diseases
… By definition, the methyl binding domain consists of about 70 residues and is the minimal
region required for binding to methylated DNA by a methyl-CpG-binding protein which binds …
region required for binding to methylated DNA by a methyl-CpG-binding protein which binds …
CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level
… domain of MBD2 exhibits distinct dynamic DNA binding mode depending on CpG density
and methylation status. These results underscore the importance of understanding how DNA …
and methylation status. These results underscore the importance of understanding how DNA …
The effect of single CpG demethylation on the pattern of DNA-protein binding
B Sobiak, W Leśniak - International Journal of Molecular Sciences, 2019 - mdpi.com
… binding proteins, including splicing factors, which suggests that demethylation of this particular
CpG … of CpGs, the density of transcription factor (TF) binding sites, and the presence of …
CpG … of CpGs, the density of transcription factor (TF) binding sites, and the presence of …
Genome-wide CpG density and DNA methylation analysis method (MeDIP, RRBS, and WGBS) comparisons
D Beck, M Ben Maamar, MK Skinner - Epigenetics, 2022 - Taylor & Francis
… the CpG density as a variable in DNA methylation analysis. … CpG density compared to a
procedure involving methylated DNA binding proteins (MBP) that is biased to higher density CpG …
procedure involving methylated DNA binding proteins (MBP) that is biased to higher density CpG …
Potential role of DNA methylation as a facilitator of target search processes for transcription factors through interplay with methyl-CpG-binding proteins
CA Kemme, R Marquez, RH Luu… - Nucleic acids …, 2017 - academic.oup.com
… CGIs are regions of DNA with a high density of CpG dinucleotides (CpGs) present within
200–3,000 bp. The human genome contains ∼25,000 CGIs, most of which are sites of …
200–3,000 bp. The human genome contains ∼25,000 CGIs, most of which are sites of …
Detection of CpG methylation level using methyl-CpG-binding domain-fused fluorescent protein
… can be applied to the simultaneous and genome-wide modified base detection systems
using microarrays coupled with modified base binding proteins fused to fluorescent proteins. …
using microarrays coupled with modified base binding proteins fused to fluorescent proteins. …
The methyl-CpG–Binding domain 2 and 3 proteins and formation of the nucleosome remodeling and deacetylase complex
G Leighton, DC Williams Jr - Journal of molecular biology, 2020 - Elsevier
… family members (MBD1–6 and methyl-CpG–binding protein 2 [MeCP2]), each of which … of
dense methylation of a CpG island, it should modify the ultimate positioning and density of the …
dense methylation of a CpG island, it should modify the ultimate positioning and density of the …
Expression regulation of genes is linked to their CpG density distributions around transcription start sites
H Tian, Y He, Y Xue, YQ Gao - Life Science Alliance, 2022 - life-science-alliance.org
… We also compared the CAP binding for highly expressed c1-TSGs and c3-TSGs and found
that CAPs with higher tissue specificities have a higher tendency to bind to c3-TSGs (Fig S1C)…
that CAPs with higher tissue specificities have a higher tendency to bind to c3-TSGs (Fig S1C)…
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