DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans

B Hwa Yun, J Guo, M Bellamri… - Mass spectrometry …, 2020 - Wiley Online Library
… and biological effects of DNA adducts, and highlight our … of cells may be appropriate for
estimating exposure and DNA … , bulky aromatic DNA adduct levels in total white blood cells

Linking the generation of DNA adducts to lung cancer

M Ceppi, A Munnia, F Cellai, M Bruzzone, MEM Peluso - Toxicology, 2017 - Elsevier
… At the current moment, there are some difficulties impeding the widespread use of adducts
in blood cells as a biomarker of lung cancer risk (Bak et al., 2006), conversely, we provide …

Quantification of Hemoglobin and White Blood Cell DNA Adducts of the Tobacco Carcinogens 2-Amino-9H-pyrido[2,3-b]indole and 4-Aminobiphenyl Formed in …

T Cai, M Bellamri, X Ming, WP Koh, MC Yu… - Chemical research in …, 2017 - ACS Publications
… white blood cells (WBC) are another surrogate blood … genotoxicants primarily by screening
of DNA adducts with 32 P-… bulky aromatic type adducts in WBC DNA of smokers compared …

Linking DNA adduct formation and human cancer risk in chemical carcinogenesis

MC Poirier - Environmental and molecular mutagenesis, 2016 - Wiley Online Library
… and in nucleated blood cells; human DNA adduct formation … between the highest DNA adduct
levels in blood cells or target … when DNA adducts are measured either in blood cell DNA or …

Acrylamide-derived DNA adducts in human peripheral blood mononuclear cell DNA: correlation with body mass

M Hemgesberg, S Stegmüller, A Cartus… - Food and Chemical …, 2021 - Elsevier
… of AA-derived DNA adducts present in humans in … DNA adduct formation and carcinogenic
outcome is of outstanding interest. Here, we investigated the levels of the major DNA adduct

The relationship between exposure to airborne particulate and DNA adducts in blood cells in an urban population of subjects with an unhealthy body mass index

A Pulliero, S Iodice, AC Pesatori, L Vigna… - International Journal of …, 2022 - mdpi.com
… and repair DNADNA adducts in blood cells, in a population of 196 adults with an unhealthy
BMI (≥25). For each subject, a DNA sample was obtained for quantification of DNA adducts

DNA adducts from anticancer drugs as candidate predictive markers for precision medicine

A Stornetta, M Zimmermann, GD Cimino… - Chemical research in …, 2017 - ACS Publications
… (106) This FA study was the first instance of low abundant cytotoxic G-NOR-G adducts
being measured in blood cells, underlying the sensitivity of HPLC-MS/MS approaches in the …

[HTML][HTML] Detection of BPDE-DNA adducts in human umbilical cord blood by LC-MS/MS analysis

L Guo, X Jiang, HY Tian, SJ Yao, BY Li… - journal of food and drug …, 2019 - Elsevier
… in umbilical cord white blood cells using the 32 P-postlabeling … exposure, measured by
DNA adducts, may adversely affect … -dG adducts in the DNA of umbilical cord white blood cell …

DNA Adducts as Biomarkers To Predict, Prevent, and Diagnose Disease—Application of Analytical Chemistry to Clinical Investigations

C Hernandez-Castillo, J Termini… - Chemical Research in …, 2019 - ACS Publications
… induces DNA adducts, these are transported by blood and … of disease, such as DNA adducts,
from most major organs as … analyze adduct levels in DNA isolated from white blood cells

DNA Adducts in Cancer Chemotherapy

Y Li - Journal of Medicinal Chemistry, 2024 - ACS Publications
DNA adducts formed by the US FDA-approved drugs. Moreover, clinical studies on DNA
adducts … This suggests the potential of monitoring DNA adducts in patient blood cells to assess …