Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer

Y Zeng, RU Jin - Seminars in cancer biology, 2022 - Elsevier
cancer. In this review, we will examine the treatments for gastric cancer including up-to-date
molecularly targeted therapies … We will then review the molecular subtypes of gastric cancer

miRNAs role in cervical cancer pathogenesis and targeted therapy: Signaling pathways interplay

AS Doghish, MA Ali, SS Elyan, MA Elrebehy… - … -Research and Practice, 2023 - Elsevier
… with CC develop early metastases of the main tumor, resulting in poor therapeutic and
prognosis outcomes [7]. A molecule-targeted therapy for CC has evolved in recent years. …

Signalling networks in cholangiocarcinoma: Molecular pathogenesis, targeted therapies and drug resistance

L Fouassier, M Marzioni, MB Afonso… - Liver …, 2019 - Wiley Online Library
… of our current understanding of the molecular pathogenesis of CCA and (b) discuss present
and future directions in the implementation of targeted therapies in CCA management. …

miRNAs role in bladder cancer pathogenesis and targeted therapy: signaling pathways interplay–a review

HA El-Mahdy, EGE Elsakka, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Bladder cancer (BC) is the 11th most popular cancer in females and 4th in males. A lot of
efforts have been exerted to improve BC patients' care. Besides, new approaches have been …

Molecular pathogenesis and targeted therapies for intrahepatic cholangiocarcinoma

A Moeini, D Sia, N Bardeesy, V Mazzaferro… - Clinical Cancer …, 2016 - AACR
Intrahepatic cholangiocarcinoma (iCCA) is a molecularly heterogeneous hepatobiliary
neoplasm with poor prognosis and limited therapeutic options. The incidence of this neoplasm is …

[HTML][HTML] Cancer cells stemness: A doorstep to targeted therapy

S Prasad, S Ramachandran, N Gupta, I Kaushik… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… Understanding the complexity of CSCs may facilitate the development of targeted therapeutic
drugs against cancer. Taken together, the major targets mentioned in this review highlight …

The interplay of signaling pathways and miRNAs in the pathogenesis and targeted therapy of esophageal cancer

AS Doghish, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Globally, esophageal cancer (EC) is the 6th leading cause of cancer-related deaths and the
second deadliest gastrointestinal cancer. Multiple genetic and epigenetic factors, such as …

[HTML][HTML] Signal pathways of melanoma and targeted therapy

W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
… of resistance to currently available targeted therapies have posed the obstacle in the …
pathogenesis more comprehensively, which might lead to more substantial progress in therapeutic

The immune system in cancer pathogenesis: potential therapeutic approaches

PH Pandya, ME Murray, KE Pollok… - Journal of …, 2016 - Wiley Online Library
… Interplay among immune activation and cancer pathogenesis provides the framework for
a novel subspecialty known as immunooncology. In the rapidly evolving field of …

[HTML][HTML] The crucial roles of Bmi-1 in cancer: implications in pathogenesis, metastasis, drug resistance, and targeted therapies

J Xu, L Li, P Shi, H Cui, L Yang - International Journal of Molecular …, 2022 - mdpi.com
… tumors, and the targeted therapy of cancer stem cells is an important measure for future
development. However, there is currently no drug that can be used clinically to target Bmi-1 …