… Eligible studies modeled the impact of a cancer risk management intervention in BRCA
carriers on life expectancy (LE), cancer incidence, or quality-adjusted life years (QALYs), with or …

… documented the uptake of risk management strategies in carriers of pathogenic variants in
… impact of cancer genetics guidelines on genetics professionals’ advice provided to carriers, …

… cancer risk and decision-making, we excluded women with a previous or current ovarian
cancer … right, and normalization of cancer risk management to participants during the decision-…

… Primary studies of BRCA mutation carriers who have undergone BRRM in … risk reduction
in breast cancer incidence. The risk of breast cancer after BRRM is less than 3%, and the risk …

… risk of 12% [1], BRCA1 and BRCA2 mutation carriers have a cumulative breast cancer risk
of… Breast cancer risk management for BRCA1/2 mutation carriers encompass the possibility of …

… management for unaffected BRCA1/2 mutation carriers and the local management of
early-stage breast cancer… There is ongoing debate about uterine cancer risk in mutation carriers. …

… detection of breast cancer in carriers, yet those are less developed for ovarian cancer.
Occasionally … and controversy in ovarian cancer risk-reducing efforts in BRCA-mutation carriers. …

… for unaffected BRCA mutation carriers and has been shown to reduce breast cancer incidence.
In our international cohort, 27.9% of the unaffected BRCA mutation carriers had bilateral …

… Prevention and early detection may have the biggest impact on morbidity and mortality
for unaffected mutation carriers (ie, those without cancer), but we know little about …

… management recommendations to reduce breast cancer risk for BRCA1/2 mutation carriers
including special populations of carriers … forms of risk reduction (Table 1). While prophylactic …